Evidence map›Paper›PMID 28384781›Full record

ArticleAnnals of internal medicine2017

Cardiometabolic Abnormalities Among Normal-Weight Persons From Five Racial/Ethnic Groups in the United States: A Cross-sectional Analysis of Two Cohort Studies.

Unjali P Gujral, Eric Vittinghoff, Morgana Mongraw-Chaffin, Dhananjay Vaidya, Namratha R Kandula, Matthew Allison, Jeffrey Carr, Kiang Liu, K M Venkat Narayan, Alka M Kanaya

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Article in Annals of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
  8. Article
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  11. Observational
  12. Article
  13. Observational
  14. Metabolic diseases in the East Asian populations.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Higher neighborhood disadvantage is associated with weaker interactions among cardiometabolic drivers.International journal of cardiology. Cardiovascular risk and prevention · 2024
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  19. Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Unjali P GujralFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Eric VittinghoffFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Morgana Mongraw-ChaffinFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Dhananjay VaidyaFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Namratha R KandulaFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Matthew AllisonFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Jeffrey CarrFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Kiang LiuFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
K M Venkat NarayanFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.
Alka M KanayaFrom Emory University, Atlanta, Georgia; University of California, San Francisco, San Francisco, and University of California, San Diego, San Diego, California; Wake Forest School of Medicine, Winston-Salem, North Carolina; Johns Hopkins University School of Medicine, Baltimore, Maryland; Northwestern University Feinberg School of Medicine, Chicago, and Northwestern University, Evanston, Illinois; and Vanderbilt University, Nashville, Tennessee.

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
Mediators of Atherosclerosis in South Asians Living in AmericaR01HL093009 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2010 to 2018
$5.4M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCRR NIH HHS UL1 RR024131NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K24 HL112827NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL093009NIDDK NIH HHS P30 DK092924NIDDK NIH HHS P30 DK098722NIDDK NIH HHS P30 DK111024
6 · The paper itself

Abstract

backgroundThe relationship between body weight and cardiometabolic disease may vary substantially by race/ethnicity.

objectiveTo determine the prevalence and correlates of the phenotype of metabolic abnormality but normal weight (MAN) for 5 racial/ethnic groups.

designCross-sectional analysis.

setting2 community-based cohorts.

participants2622 white, 803 Chinese American, 1893 African American, and 1496 Hispanic persons from MESA (Multi-Ethnic Study of Atherosclerosis) and 803 South Asian participants in the MASALA (Mediators of Atherosclerosis in South Asians Living in America) study. MEASUREMENTS: Prevalence of 2 or more cardiometabolic abnormalities (high fasting glucose, low high-density lipoprotein cholesterol, and high triglyceride levels and hypertension) among normal-weight participants was estimated. Correlates of MAN were assessed by using log-binomial models.

resultsAmong normal-weight participants (n = 846 whites, 323 Chinese Americans, 334 African Americans, 252 Hispanics, and 195 South Asians), the prevalence of MAN was 21.0% (95% CI, 18.4% to 23.9%) in whites, 32.2% (CI, 27.3% to 37.4%) in Chinese Americans, 31.1% (CI, 26.3% to 36.3%) in African Americans, 38.5% (CI, 32.6% to 44.6%) in Hispanics, and 43.6% (CI, 36.8% to 50.6%) in South Asians. Adjustment for demographic, behavioral, and ectopic body fat measures did not explain racial/ethnic differences. After adjustment for age, sex, and race/ethnicity-body mass index (BMI) interaction, for the equivalent MAN prevalence at a BMI of 25.0 kg/m2 in whites, the corresponding BMI values were 22.9 kg/m2 (CI, 19.5 to 26.3 kg/m2) in African Americans, 21.5 kg/m2 (CI, 18.5 to 24.5 kg/m2) in Hispanics, 20.9 kg/m2 (CI, 19.7 to 22.1 kg/m2) in Chinese Americans, and 19.6 kg/m2 (CI, 17.2 to 22.0 kg/m2) in South Asians. LIMITATION: Cross-sectional study design and lack of harmonized dietary data between studies.

conclusionCompared with whites, all racial/ethnic minority groups had a statistically significantly higher prevalence of MAN, which was not explained by demographic, behavioral, or ectopic fat measures. Using a BMI criterion for overweight to screen for cardiometabolic risk may result in a large proportion of racial/ethnic minority groups being overlooked. PRIMARY FUNDING SOURCE: National Institutes of Health.

Indexed as

Body WeightAdultAgedAged, 80 and overAsianBlack or African AmericanBody Mass IndexCardiovascular DiseasesCross-Sectional StudiesFemaleHispanic or LatinoHumansMaleMetabolic DiseasesMiddle AgedPhenotype

Identifiers

PMID28384781
PMCPMC5545925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.