Evidence map›Paper›PMID 28384703›Full record

ArticleJournal of biomedical optics2017

Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy.

Hossein S Yazdi, Thomas D O'Sullivan, Anais Leproux, Brian Hill, Amanda Durkin, Seraphim Telep, Jesse Lam, Siavash S Yazdi, Alice M Police, Robert M Carroll and 4 more

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hossein S YazdiUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Thomas D O'SullivanUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Anais LeprouxUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Brian HillUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Amanda DurkinUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Seraphim TelepUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Jesse LamUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Siavash S YazdiUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Alice M PoliceUniversity of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
Robert M CarrollUniversity of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
Freddie J CombsUniversity of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
Tomas StrömbergUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United StatescLinköping University, Department of Biomedical Engineering, Linköping, Sweden.
Arjun G YodhUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
Bruce J TrombergUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI VENUGOPALAN, VASAN · 2012 to 2017
$7.0M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Developing DOSI Technology for Monitoring Response To Breast Cancer ChemotherapyR01CA142989 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2010 to 2017
$4.1M
Monitoring Breast Cancer Chemotherapeutic Response Using DOSI, MRI and BiomarkersU54CA136400 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI TROMBERG, BRUCE J. · 2009 to 2011
$1.3M
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA142989NCI NIH HHS U54 CA136400NIBIB NIH HHS P41 EB015890NIBIB NIH HHS P41 EB015893NINDS NIH HHS R01 NS060653
6 · The paper itself

Abstract

Diffuse optical spectroscopic imaging (DOSI) and diffuse correlation spectroscopy (DCS) are model-based near-infrared (NIR) methods that measure tissue optical properties (broadband absorption, ? a , and reduced scattering, ? s ? ) and blood flow (blood flow index, BFI), respectively. DOSI-derived ? a values are used to determine composition by calculating the tissue concentration of oxy- and deoxyhemoglobin ( HbO 2 , HbR), water, and lipid. We developed and evaluated a combined, coregistered DOSI/DCS handheld probe for mapping and imaging these parameters. We show that uncertainties of 0.3 ?? mm ? 1 (37%) in ? s ? and 0.003 ?? mm ? 1 (33%) in ? a lead to ? 53 % and 9% errors in BFI, respectively. DOSI/DCS imaging of a solid tissue-simulating flow phantom and

Indexed as

AdultCarcinoma, Ductal, BreastDiffusionFemaleHemoglobinsHumansLipidsModels, TheoreticalNeoadjuvant TherapyOxyhemoglobinsPhantoms, ImagingSpectrophotometrySpectroscopy, Near-InfraredTomography, OpticaldeoxyhemoglobinHemoglobinsLipidsOxyhemoglobins

Identifiers

PMID28384703
PMCPMC5381696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.