ArticleDrug and alcohol dependence2017
Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4T.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Intermittent theta burst to the left dorsolateral prefrontal cortex promoted decreased alcohol consumption and improved outcomes in those with alcohol use disorder: A randomized, double-blind, placebo-controlled clinical trial.Drug and alcohol dependence · 2025Trial
- Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review.Current addiction reports · 2025Article
- Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder.Frontiers in psychiatry · 2025Article
- Altered individual gray matter structural covariance networks in early abstinence patients with alcohol dependence.Brain imaging and behavior · 2024Article
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Relating white matter microstructure in theoretically defined addiction networks to relapse in alcohol use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia.Alcohol (Fayetteville, N.Y.) · 2023Review
- Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study.Alcoholism, clinical and experimental research · 2021Article
- Alterations in connectivity of the bed nucleus of the stria terminalis during early abstinence in individuals with alcohol use disorder.Alcoholism, clinical and experimental research · 2021Article
- White matter microstructural and Compulsive Sexual Behaviors Disorder - Diffusion Tensor Imaging study.Journal of behavioral addictions · 2021Review
- Evaluating the Changes of White Matter Microstructures in Tobacco Addicts Based on Diffusion Tensor Imaging.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence.JAMA psychiatry · 2019Article
- Selective micro-structural integrity impairment of the isthmus subregion of the corpus callosum in alcohol-dependent males.BMC psychiatry · 2019Article
- White matter microstructural correlates of relapse in alcohol dependence.Psychiatry research. Neuroimaging · 2018Article
- Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Article
- Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe previously reported widespread microstructural deficits of brain white matter in alcohol-dependent individuals (ALC) compared to light drinkers in a small 1.5T diffusion tensor imaging study employing tract-based spatial statistics. Using a larger dataset acquired at 4T, the present study is an extension that investigated the effects of alcohol consumption, abstinence from alcohol, and comorbid cigarette smoking on white matter microstructure.
methodsTract-based spatial statistics were performed on 20 1-week-abstinent ALC, 52 1-month-abstinent ALC, and 30 controls. Regional measures of fractional anisotropy (FA) and mean diffusivity (MD) in the significant clusters were compared by Analysis of Covariance. The metrics were correlated with substance use history and behavioral measures.
results1-week-abstinent ALC showed lower FA than controls in the corpus callosum, right cingulum, external capsule, and hippocampus. At 1 month of abstinence, only the FA in the body of the corpus callosum of ALC remained significantly different from controls. Some regional FA deficits correlated with more severe measures of drinking and smoking histories but only weakly with mood and impulsivity measures.
conclusionWhite matter microstructure is abnormal during early abstinence in alcohol dependent treatment seekers and recovers into the normal range within about four weeks. The compromised white matter was related to substance use severity, mood, and impulsivity. Our findings suggest that ALC may benefit from interventions that facilitate normalization of DTI metrics to maintain abstinence, via smoking cessation, cognitive-based therapy, and perhaps pharmacology to support remyelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.