Evidence map›Paper›PMID 28384492›Full record

ArticleBiomaterials2017

Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness.

Soah Lee, Vahid Serpooshan, Xinming Tong, Sneha Venkatraman, Meelim Lee, Jaecheol Lee, Orlando Chirikian, Joseph C Wu, Sean M Wu, Fan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Patient-specific 3DFrontiers in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Soah LeeDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Vahid SerpooshanStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Xinming TongDepartment of Orthopedic Surgery, Stanford, CA, USA.
Sneha VenkatramanStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Biology Program, California State University Channel Islands, Camarillo, CA, USA.
Meelim LeeDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Jaecheol LeeStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Orlando ChirikianStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Biology Program, California State University Channel Islands, Camarillo, CA, USA.
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Sean M WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA. Electronic address: smwu@stanford.edu.
Fan YangDepartment of Orthopedic Surgery, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA. Electronic address: fanyang@stanford.edu.

Funding

Induced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2M
Microribbon scaffold-mediated Immunomodulation for Cranial Bone RepairR01DE024772 · NIDCR · STANFORD UNIVERSITY · PI YANG, FAN · 2015 to 2025
$4.6M
Enabling Technologies for Human-Machine Hybrid TissuesDP1LM012179 · NLM · STANFORD UNIVERSITY · PI WU, SEAN M · 2014 to 2018
$3.8M
Molecular Imaging of Cardiac Pluripotent Stem CellsR01HL133272 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2020
$2.4M
Molecular and Cellular Mechanisms of Neonatal Cardiac Development and RepairK99HL127295 · NHLBI · STANFORD UNIVERSITY · PI SERPOOSHAN, VAHID · 2016 to 2017
$238k
NHLBI NIH HHS K99 HL127295NHLBI NIH HHS R01 HL133272NHLBI NIH HHS U01 HL099776NIDCR NIH HHS R01 DE024772NLM NIH HHS DP1 LM012179
6 · The paper itself

Abstract

Engineering 3D human cardiac tissues is of great importance for therapeutic and pharmaceutical applications. As cardiac tissue substitutes, extracellular matrix-derived hydrogels have been widely explored. However, they exhibit premature degradation and their stiffness is often orders of magnitude lower than that of native cardiac tissue. There are no reports on establishing interconnected cardiomyocytes in 3D hydrogels at physiologically-relevant cell density and matrix stiffness. Here we bioengineer human cardiac microtissues by encapsulating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in chemically-crosslinked gelatin hydrogels (1.25 × 10

Indexed as

Biocompatible MaterialsBiomechanical PhenomenaBiomimeticsCell CommunicationCell DifferentiationCells, CulturedCells, ImmobilizedCross-Linking ReagentsElasticityGelatinHumansHydrogelsInduced Pluripotent Stem CellsMyocytes, CardiacTissue EngineeringBiocompatible MaterialsCross-Linking ReagentsGelatinHydrogelsCardiac tissue engineeringDegradationGelatin hydrogelsHuman induced pluripotent stem cell-derived cardiomyocytesStiffness

Identifiers

PMID28384492
PMCPMC5558787

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.