Evidence map›Paper›PMID 28384471›Full record

ReviewNeuron2017

Sleep and Human Aging.

Bryce A Mander, Joseph R Winer, Matthew P Walker

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 595 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
595citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

595 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Trial
  8. Trial
  9. Effects of inhaled aromatherapy on sleep quality and cognitive function in older adults: a randomised controlled trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Trial
  10. Trial
  11. Trial
  12. Comorbid insomnia and sleep apnea is associated with worse verbal episodic memory in older females.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Article
  17. Article
  18. Presurgical Sleep-Wake Disturbance and Postoperative Delirium: A Prospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
  19. Article
  20. Association of vitamin D and B12 levels with actigraphic sleep in cognitively unimpaired middle-aged and older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article

535 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bryce A ManderSleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, Berkeley, CA 94720-1650, USA.
Joseph R WinerSleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, Berkeley, CA 94720-1650, USA.
Matthew P WalkerSleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, Berkeley, CA 94720-1650, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720-1650, USA. Electronic address: mpwalker@berkeley.edu.

Funding

Tau pathology, sleep disruption, and hippocampal memory decline in older adultsRF1AG054106 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WALKER, MATTHEW P · 2017 to 2018
$4.7M
Sleep Loss, Human Memory and Brain Plasticity across the LifespanR01AG031164 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WALKER, MATTHEW P · 2008 to 2019
$4.7M
A sleep electroencephalography biomarker predicting Alzheimer's disease pathologyRF1AG054019 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WALKER, MATTHEW P · 2016 to 2016
$4.1M
Anxiety, sleep disruption and emotional brain dysregulationR01MH093537 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI WALKER, MATTHEW P · 2012 to 2016
$1.6M
NIA NIH HHS R01 AG031164NIA NIH HHS RF1 AG054019NIA NIH HHS RF1 AG054106NIMH NIH HHS R01 MH093537
6 · The paper itself

Abstract

Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity and quality occur as we age, and are there functional consequences? What are the underlying neural mechanisms that explain age-related sleep disruption? This review tackles these questions. First, we describe canonical changes in human sleep quantity and quality in cognitively normal older adults. Second, we explore the underlying neurobiological mechanisms that may account for these human sleep alterations. Third, we consider the functional consequences of age-related sleep disruption, focusing on memory impairment as an exemplar. We conclude with a discussion of a still-debated question: do older adults simply need less sleep, or rather, are they unable to generate the sleep that they still need?

Indexed as

AgingBrainBrain WavesHumansMemory DisordersPolysomnographySleepSleep Wake DisordersagingAlzheimer’s diseasebrain stimulationdementiamemorynon-rapid eye movement sleeprapid eye movement sleepsleepsleep spindlesslow waves

Identifiers

PMID28384471
PMCPMC5810920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.