ReviewJournal of dental research2017
Second Era of OMICS in Caries Research: Moving Past the Phase of Disillusionment.
Review in Journal of dental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- An oral health optimized diet reduces the load of potential cariogenic and periodontal bacterial species in the supragingival oral plaque: A randomized controlled pilot study.MicrobiologyOpen · 2020Trial
- Mechanisms of caries induced by sugars: a narratives review from microbial metabolism to oral ecological imbalance and public health strategies for caries prevention.Frontiers in cellular and infection microbiology · 2026Review
- Construction of an early childhood caries risk prediction model based on the oral microbiome: a nested case‒control study.BMC oral health · 2025Article
- Salivary Proteins and Metabolites as Caries Biomarkers in Adolescents.Caries research · 2024Article
- Sweet Orange Juice Processing By-Product Extracts: A Caries Management Alternative to Chlorhexidine.Biomolecules · 2023Article
- The Baker Lab at the OHSU School of Dentistry: leveraging bioinformatics and molecular biology to discover how the bacteria that live in our mouth impact human health and disease.OHSU School of Dentistry anthology · 2023Article
- Metataxonomic and metabolomic evidence of biofilm homeostasis disruption related to caries: An in vitro study.Molecular oral microbiology · 2022Article
- Metabolomics Insights in Early Childhood Caries.Journal of dental research · 2021Article
- Analysis of relative bacterial activity and lactate dehydrogenase gene expression of caries-associated bacteria in a site-specific natural biofilm: an ex vivo study.Clinical oral investigations · 2021Article
- Can Probiotics Emerge as Effective Therapeutic Agents in Apical Periodontitis? A Review.Probiotics and antimicrobial proteins · 2021Review
- Bacterial Composition and Metabolomics of Dental Plaque From Adolescents.Frontiers in cellular and infection microbiology · 2021Article
- Identification of Oral Bacterial Biosynthetic Gene Clusters Associated with Caries.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Grand Challenges in Oral Infections and Microbes.Frontiers in oral health · 2020Article
- Approaches to Modulate Biofilm Ecology.Dental clinics of North America · 2019Review
- Correlation between relative bacterial activity and lactate dehydrogenase gene expression of co-cultures in vitro.Clinical oral investigations · 2019Article
- The Supragingival Biofilm in Early Childhood Caries: Clinical and Laboratory Protocols and Bioinformatics Pipelines Supporting Metagenomics, Metatranscriptomics, and Metabolomics Studies of the Oral Microbiome.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Bacterial biofilm composition in healthy subjects with and without caries experience.Journal of oral microbiology · 2019Article
- Biology of Oral Streptococci.Microbiology spectrum · 2018Review
- Meeting report: a close look at oral biofilms and microbiomes.International journal of oral science · 2018Article
- Potential Uses of Arginine in Dentistry.Advances in dental research · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Novel approaches using OMICS techniques enable a collective assessment of multiple related biological units, including genes, gene expression, proteins, and metabolites. In the past decade, next-generation sequencing ( NGS) technologies were improved by longer sequence reads and the development of genome databases and user-friendly pipelines for data analysis, all accessible at lower cost. This has generated an outburst of high-throughput data. The application of OMICS has provided more depth to existing hypotheses as well as new insights in the etiology of dental caries. For example, the determination of complete bacterial microbiomes of oral samples rather than selected species, together with oral metatranscriptome and metabolome analyses, supports the viewpoint of dysbiosis of the supragingival biofilms. In addition, metabolome studies have been instrumental in disclosing the contributions of major pathways for central carbon and amino acid metabolisms to biofilm pH homeostasis. New, often noncultured, oral streptococci have been identified, and their phenotypic characterization has revealed candidates for probiotic therapy. Although findings from OMICS research have been greatly informative, problems related to study design, data quality, integration, and reproducibility still need to be addressed. Also, the emergence and continuous updates of these computationally demanding technologies require expertise in advanced bioinformatics for reliable interpretation of data. Despite the obstacles cited above, OMICS research is expected to encourage the discovery of novel caries biomarkers and the development of next-generation diagnostics and therapies for caries control. These observations apply equally to the study of other oral diseases.
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Registered trials
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