ArticlePloS one2017
Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model.Pharmaceutics · 2022Article
- Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon: The Influence of Different Motility Patterns and Fluid Viscosities.Pharmaceutics · 2021Article
- The virtual physiological human gets nerves! How to account for the action of the nervous system in multiphysics simulations of human organs.Journal of the Royal Society, Interface · 2021Article
- Combined Peridynamics and Discrete Multiphysics to Study the Effects of Air Voids and Freeze-Thaw on the Mechanical Properties of Asphalt.Materials (Basel, Switzerland) · 2021Article
- The role of valve stiffness in the insurgence of deep vein thrombosis.Communications materials · 2020Article
- Article
- Fluid-structure interaction of blood flow around a vein valve.BioImpacts : BI · 2020Article
- Article
- Effect of valve lesion on venous valve cycle: A modified immersed finite element modeling.PloS one · 2019Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves.
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