ArticlePloS one2017
Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pooled it
- (-)-Epicatechin accelerates muscle repair and promotes hypertrophy in type 2 fibers of BaCl2-damaged gastrocnemius in CD1 mice.Journal of molecular histology · 2026Article
- Skeletal Muscle Aging: Enhancing Skeletal Muscle Integrity and Function as a Potential Pharmacological Approach.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Interaction of Programmed Obesity and Postnatal High Fat Diet but Not (-)-Epicatechin Treatment Modifies Muscle Atrophy Proteins Levels in Male Wistar Rats.Cell biochemistry and biophysics · 2025Article
- Epicatechin Gallate Regulation of Steroid Hormone Levels Improves Sarcopenia in C57BL/6J Mice.Foods (Basel, Switzerland) · 2025Article
- The beneficial therapeutic effects of plant-derived natural products for the treatment of sarcopenia.Journal of cachexia, sarcopenia and muscle · 2022Review
- Naringenin Promotes Myotube Formation and Maturation for Cultured Meat Production.Foods (Basel, Switzerland) · 2022Article
- (-)-Epicatechin Is a Biased Ligand of Apelin Receptor.International journal of molecular sciences · 2022Article
- Restorative potential of (-)-epicatechin in a rat model of Gulf War illness muscle atrophy and fatigue.Scientific reports · 2021Article
- Polyphenols and Their Effects on Muscle Atrophy and Muscle Health.Molecules (Basel, Switzerland) · 2021Review
- Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism.Frontiers in nutrition · 2021Article
- Flavonoids: nutraceutical potential for counteracting muscle atrophy.Food science and biotechnology · 2020Review
- PXR is a target of (-)-epicatechin in skeletal muscle.Heliyon · 2020Article
- Effects of tannase-converted green tea extract on skeletal muscle development.BMC complementary medicine and therapies · 2020Article
- Tannase-Converted Green Tea Extract with High (-)-Epicatechin Inhibits Skeletal Muscle Mass in Aged Mice.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation.Cell death and differentiation · 2020Article
- (-)-Epicatechin stimulates mitochondrial biogenesis and cell growth in C2C12 myotubes via the G-protein coupled estrogen receptor.European journal of pharmacology · 2018Article
- Ginsenoside Rg1 fromJournal of ginseng research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt. EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein. Consistently, EC also positively regulated myogenic conversion and differentiation of fibroblasts. In conclusion, EC has a potential as a therapeutic or nutraceutical remedy to treat degenerative muscle diseases or age-related muscle weakness.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.