Evidence map›Paper›PMID 28384207›Full record

SynthesisPloS one2017

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis.

Jinhua Zhang, Xudong Sun, Jiemin Wang, Fuhua Zhang, Xiaohua Li, Jian Han

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jinhua ZhangDepartment of Gastroenterology, Second Hospital of Gansu Province, Lanzhou, China.
Xudong SunDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Jiemin WangDepartment of Gastroenterology, Liangzhou Hospital, Wuwei, China.
Fuhua ZhangDepartment of Gastroenterology, Second Hospital of Gansu Province, Lanzhou, China.
Xiaohua LiDepartment of Gastroenterology, Liangzhou Hospital, Wuwei, China.
Jian HanDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.ORCID http://orcid.org/0000-0002-4884-5905
Lanzhou University · CNNorthwest Minzu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02-1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00-1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.

Indexed as

Minisatellite RepeatsPolymorphism, GeneticHelicobacter InfectionsHelicobacter pyloriHumansInterleukin 1 Receptor Antagonist ProteinIL1RN protein, humanInterleukin 1 Receptor Antagonist Protein

Identifiers

PMID28384207
PMCPMC5383105
OpenAlexW2604694804

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.