ArticlePloS one2017
Silent dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- [Prevalence of HTLV-1 infection in family members of index cases in PeruPrevalência familiar da infecção pelo HTLV-1 a partir de um caso índice no Peru].Revista panamericana de salud publica = Pan American journal of public health · 2026Article
- Stability and Perpetuation of Human T-Lymphotropic Virus 1 (HTLV-1) in Intrafamilial Transmissions of Infection in an Endemic Region of the Brazilian Amazon: A Pilot Study.Journal of tropical medicine · 2025Article
- Article
- Epidemiological and molecular evidence of intrafamilial transmission through sexual and vertical routes in Bahia, the state with the highest prevalence of HTLV-1 in Brazil.PLoS neglected tropical diseases · 2023Article
- Genetic typing and intrafamilial transmission of human T-lymphotropic virus type 1 in non-endemic areas of China.Frontiers in microbiology · 2023Article
- Spread of Human T-Lymphotropic Virus 1 and 2 Among Relatives of People Who Use Illicit Drugs in Northern Brazil.Frontiers in microbiology · 2022Article
- Review
- Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques.Retrovirology · 2020Article
- First Description of Seronegative HTLV-1 Carriers in Argentina.The American journal of tropical medicine and hygiene · 2020Article
- The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil.Retrovirology · 2020Review
- A 17-Year-Old Boy With Right Face Palsy, Left Leg Weakness, and Lytic Skull-Bone Lesions.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Estimation of HTLV-1 vertical transmission cases in Brazil per annum.PLoS neglected tropical diseases · 2018Article
- Family Aggregation of HTLV-1 Infection Associated with FAS -670A/G Polymorphism: A Case Report.Frontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMolecular and epidemiological studies of transmission routes and risk factors for infection by HTLV-1 are extremely important in order to implement control measures, especially because of the high prevalence of HTLV-1 in several regions of the world. San Salvador de Jujuy, Northwest Argentina, is a highly endemic area for HTLV-1 and foci of tropical spastic paraparesis/HTLV-1-associated myelopathy.
objectiveTo gain further insight into the role of intrafamilial transmission of HTLV-1 in a highly endemic region in Argentina.
methodCross-sectional study in Northwest Argentina. Epidemiological data and blood samples were collected from 28 HTLV-1 infected subjects (index cases) and 92 close relatives/cohabitants. HTLV-1 infection was diagnosed by detection of antibodies and proviral DNA. The LTR region was sequenced and analyzed for genetic distances (VESPA software), in addition to determination and identification of polymorphisms to define HTLV-1 family signatures.
resultsFifty seven of the 120 subjects enrolled had antibodies against HTLV-1 and were typified as HTLV-1 by PCR. The prevalence rate of HTLV-1 infection in family members of infected index cases was 31.52% (29/92). The infection was significantly associated with gender, age and prolonged lactation. Identity of LTR sequences and presence of polymorphisms revealed high prevalence of mother-to-child and interspousal transmission of HTLV-1 among these families.
conclusionThere is an ongoing and silent transmission of HTLV-1 through vertical and sexual routes within family clusters in Northwest Argentina. This evidence highlights that HTLV-1 infection should be considered as a matter of public health in Argentina, in order to introduce preventive measures as prenatal screening and breastfeeding control.
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