Evidence map›Paper›PMID 28383826›Full record

ArticleThe Journal of physiology2017

Phosphatidylinositol 4,5-bisphosphate (PIP

Matthew K Kirchner, Robert C Foehring, Lie Wang, Giri Kumar Chandaka, Joseph C Callaway, William E Armstrong

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Striking a balance: PIPExploration of neuroprotective therapy · 2021
    Article
  4. Modulation of KFrontiers in pharmacology · 2020
    Article
  5. PIPPhysiological reports · 2019
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Matthew K KirchnerDepartment of Anatomy and Neurobiology and Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0001-6960-7685
Robert C FoehringDepartment of Anatomy and Neurobiology and Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
Lie WangDepartment of Anatomy and Neurobiology and Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
Giri Kumar ChandakaDepartment of Anatomy and Neurobiology and Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
Joseph C CallawayDepartment of Anatomy and Neurobiology and Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
William E ArmstrongDepartment of Anatomy and Neurobiology and Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
University of Tennessee Health Science Center · US

Funding

Slowly Inactivating K+ Channels in Pyramidal NeuronsR01NS044163 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI FOEHRING, ROBERT C, SPAIN, WILLIAM J · 2003 to 2022
$6.5M
Reproductive Plasticity in Oxytocin NeuronsR01HD072056 · NICHD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ARMSTRONG, WILLIAM E · 2013 to 2017
$1.5M
NICHD NIH HHS R01 HD072056NINDS NIH HHS R01 NS044163
6 · The paper itself

Abstract

key pointsAfterhyperpolarizations (AHPs) generated by repetitive action potentials in supraoptic magnocellular neurons regulate repetitive firing and spike frequency adaptation but relatively little is known about PIP ABSTRACT: Oxytocin (OT)- and vasopressin (VP)-secreting magnocellular neurons of the supraoptic nucleus (SON) display calcium-dependent afterhyperpolarizations (AHPs) following a train of action potentials that are critical to shaping the firing patterns of these cells. Previous work demonstrated that the lipid phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

Action PotentialsAndrostadienesAnimalsFemaleIn Vitro TechniquesNeuronsOxytocinPhosphatidylinositol 4,5-DiphosphateRats, Sprague-DawleySupraoptic NucleusWortmanninAndrostadienesOxytocinPhosphatidylinositol 4,5-DiphosphateWortmanninafter-hyperpolarizationafter-hyperpolarization currentcaged calciumcalciumoxytocinPIP2

Identifiers

PMID28383826
PMCPMC5509854
OpenAlexW2746247256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.