Evidence map›Paper›PMID 28383804›Full record

ReviewClinical and translational science2017

Gene Therapy 2017: Progress and Future Directions.

A M Keeler, M K ElMallah, T R Flotte

Abstract readReview
In one paragraph

Review in Clinical and translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Turning "trashed" genomic loci into treasurable sites for integrating chimeric antigen receptors in T and NK cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  2. Review
  3. Trends analysis and future study of the pharmaceutical industry field: a scoping review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. New strategies for neuro protection in glaucoma.Frontiers in cell and developmental biology · 2022
    Review
  12. Viral vector-based gene therapies in the clinic.Bioengineering & translational medicine · 2022
    Review
  13. Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021
    Review
  14. Review
  15. Review
  16. Recent Advances in Stimulus-Responsive Nanocarriers for Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  17. Advanced genetic engineering to achieve in vivo targeting of adenovirus utilizing camelid single domain antibody.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  18. Review
  19. Article
  20. Molecular therapy. Methods & clinical development · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A M KeelerHorae Gene Therapy Center and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
M K ElMallahHorae Gene Therapy Center and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
T R FlotteHorae Gene Therapy Center and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Funding

Viral Vector CoreP01HL131471 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FLOTTE, TERENCE R. · 2016 to 2020
$11.3M
Nuclease free gene editing approaches to treat alpha-1 antitrypsin diseaseR01DK098252 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FLOTTE, TERENCE R. · 2013 to 2022
$3.0M
Novel Approaches for Correcting Respiratory Insufficiency in Pompe DiseaseK08HD077040 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ELMALLAH, MAI · 2014 to 2018
$690k
Gene Therapy for Upper Airway and Respiratory Insufficiency in an ALS Mouse ModelR21NS098131 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ELMALLAH, MAI · 2016 to 2017
$447k
NHLBI NIH HHS P01 HL131471NICHD NIH HHS K08 HD077040NIDDK NIH HHS R01 DK098252NINDS NIH HHS R21 NS098131
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

RNA InterferenceAdenoviridaeCRISPR-Cas SystemsDrug ApprovalGammaretrovirusGene EditingGenetic TherapyGenetic VectorsHumansLentivirusOncolytic Viruses

Identifiers

PMID28383804
PMCPMC5504480

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.