ArticleChemical senses2017
Phosphorus Taste Involves T1R2 and T1R3.
Article in Chemical senses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat.Function (Oxford, England) · 2024Article
- Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular chloride ion.Scientific reports · 2023Article
- Eat like a Pig to Combat Obesity.Metabolites · 2023Article
- In defense of elemental currencies: can ecological stoichiometry stand as a framework for terrestrial herbivore nutritional ecology?Oecologia · 2022Review
- Understanding the evolution of nutritive taste in animals: Insights from biological stoichiometry and nutritional geometry.Ecology and evolution · 2021Review
- Variable Branching Characteristics of Peripheral Taste Neurons Indicates Differential Convergence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Characterizing Dysgeusia in Hemodialysis Patients.Chemical senses · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rodents consume solutions of phosphates and pyrophosphates in preference to water. Recently, we found that the preference for trisodium pyrophosphate (Na3HP2O7) was greater in T1R3 knockout (KO) mice than wild-type (WT) controls, suggesting that T1R3 is a pyrophosphate detector. We now show that this heightened Na3HP2O7 preference of T1R3 KO mice extends to disodium phosphate (Na2HPO4), disodium and tetrasodium pyrophosphate (Na2H2PO4 and Na4H2PO4), a tripolyphosphate (Na5P3O10), a non-sodium phosphate [(NH4)2HPO4], and a non-sodium pyrophosphate (K4P2O7) but not to non-P salts with large anions (sodium gluconate, acetate, or propionate). Licking rates for Na3HP2O7 are higher in T1R2 KO mice than WT controls; Na3HP2O7 preference scores are increased even more in T1R2 KO mice and T1R2+T1R3 double KO mice than in T1R3 KO mice; preference scores for Na3HP2O7 are normal in T1R1 KO mice. These results implicate each subunit of the T1R2+T1R3 dimer in the behavioral response to P-containing taste compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.