Evidence map›Paper›PMID 28383553›Full record

ArticleCell death & disease2017

Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain.

Wei Yu, Manasa Gowda, Yashsavi Sharad, Surindo A Singh, Federico Sesti

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Antagonistic roles of Ras-MAPK and Akt signaling in integrin-KFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  8. Article
  9. Src Mediates Epigallocatechin-3-Molecules (Basel, Switzerland) · 2020
    Article
  10. Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticityFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei YuDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, USA.
Manasa GowdaDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, USA.
Yashsavi SharadDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, USA.
Surindo A SinghDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, USA.
Federico SestiDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, USA.
Rutgers, The State University of New Jersey · US

Funding

Oxidation of K+ channels mediates an amyloidogenic pathway common to Alzheimer's disease and TBIR01AG060919 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SESTI, FEDERICO · 2019 to 2023
$2.0M
Oxidative modification of K+ channels as a mechanism of toxicity in TBIR21NS096619 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI SESTI, FEDERICO · 2016 to 2017
$432k
NIA NIH HHS R01 AG060919NINDS NIH HHS R21 NS096619
6 · The paper itself

Abstract

Oxidative modification of the voltage-gated potassium (K

Indexed as

Amino Acid SubstitutionAnimalsApoptosisBrainCHO CellsCricetinaeCricetulusFocal Adhesion Kinase 1Integrin alpha5MiceMutation, MissenseProto-Oncogene Proteins c-fynShab Potassium ChannelsSignal Transductionsrc-Family KinasesFocal Adhesion Kinase 1Fyn protein, mouseIntegrin alpha5Kcnb1 protein, mouseProto-Oncogene Proteins c-fynPtk2 protein, mouseShab Potassium Channelssrc-Family Kinases

Identifiers

PMID28383553
PMCPMC5477583
OpenAlexW2604224100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.