Evidence map›Paper›PMID 28383537›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2017

In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia.

W Jackson, C P Hornik, J A Messina, K Guglielmo, A Watwe, G Delancy, A Valdez, T MacArthur, S Peter-Wohl, P B Smith and 2 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04447989 (Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04447989 phase2completednot on this mapstarted 2021, after this paper: background citation

Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia

TypeinterventionalSponsorChristoph HornikRan2021 to 2025Enrolled125ConditionsBronchopulmonary Dysplasia of NewbornArmsSildenafil, Placebo
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Outcomes of infants with severe bronchopulmonary dysplasia in the pediatric intensive care unit.Pediatrics international : official journal of the Japan Pediatric Society · 2021
    Article
  8. Article
  9. Article
  10. Predictors of length of stay for initial hospitalization in infants with bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

W JacksonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
C P HornikDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
J A MessinaDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
K GuglielmoDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
A WatweDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
G DelancyDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
A ValdezDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
T MacArthurDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
S Peter-WohlDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
P B SmithDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
V N ToliaPediatrix-Obstetrix Center for Research and Education, Sunrise, FL, USA.
M M LaughonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Duke Medical Center · USUniversity of North Carolina at Chapel Hill · USClinical Research Institute · US

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Molecular Mechanisms Associated with Immune Maturation in InfantsR01AI100067 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DE PARIS, KRISTINA · 2012 to 2015
$1.8M
Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTGT32AI100851 · NIAID · DUKE UNIVERSITY · PI ALEXANDER, BARBARA D · 2013 to 2022
$1.8M
Mentorship of early-career pediatricians in quantitiative methods and therapeuticK24HD058735 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2009 to 2018
$1.5M
Safety of furosemide in premature infants at risk of bronchopulmonary dysplasiaR01FD005101 · FDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2016 to 2018
$1.1M
NIH Summer Research Experience Programs (R25)R25HD076475 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2013 to 2023
$1.1M
Echocardiogram to Diagnose Pulmonary Hypertension in Premature InfantsR34HL124038 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2015 to 2016
$719k
PATIENT SAFETY RESEARCH DURING NEONATAL CARE (R21)R21HD080606 · NICHD · DUKE UNIVERSITY · PI SMITH, PHILLIP BRIAN · 2015 to 2016
$457k
FDA HHS R01 FD005101NCATS NIH HHS UL1 TR001117NHLBI NIH HHS R34 HL124038NIAID NIH HHS R01 AI100067NIAID NIH HHS T32 AI100851NICHD NIH HHS HHSN267200700051CNICHD NIH HHS HHSN275201000003CNICHD NIH HHS HHSN275201000003INICHD NIH HHS K24 HD058735NICHD NIH HHS R21 HD080606NICHD NIH HHS R25 HD076475
6 · The paper itself

Abstract

objectiveTo characterize in-hospital outcomes of premature infants diagnosed with severe bronchopulmonary dysplasia (BPD). STUDY

designRetrospective cohort study including premature infants with severe BPD discharged from 348 Pediatrix Medical Group neonatal intensive care units from 1997 to 2015.

resultsThere were 10 752 infants with severe BPD, and 549/10 752 (5%) died before discharge. Infants who died were more likely to be male, small for gestational age, have received more medical interventions and more frequently diagnosed with surgical necrotizing enterocolitis, culture-proven sepsis and pulmonary hypertension following 36 weeks of postmenstrual age compared with survivors. Approximately 70% of infants with severe BPD were discharged by 44 weeks of postmenstrual age, and 86% were discharged by 48 weeks of postmenstrual age.

conclusionsA majority of infants diagnosed with severe BPD were discharged home by 44 weeks of postmenstrual age. These results may inform discussions with families regarding the expected hospital course of infants diagnosed with severe BPD.

Indexed as

Bronchopulmonary DysplasiaElectronic Health RecordsEnterocolitis, NecrotizingFemaleGestational AgeHumansHypertension, PulmonaryInfantInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornInfant, Small for Gestational AgeIntensive Care Units, NeonatalMaleNorth CarolinaPatient Discharge

Identifiers

PMID28383537
PMCPMC5562519
OpenAlexW2604149529

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.