ArticleJournal of perinatology : official journal of the California Perinatal Association2017
The immature platelet fraction: creating neonatal reference intervals and using these to categorize neonatal thrombocytopenias.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A CBC drawn postnatally from umbilical cord blood can provide valuable diagnostic information for infants admitted to the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Observational
- Implementing evidence-based restrictive neonatal intensive care unit platelet transfusion guidelines.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Why might cord blood be a better source of platelets for transfusion to neonates?Blood transfusion = Trasfusione del sangue · 2024Review
- Hemostatic Profile of Intrauterine Growth-Restricted Neonates: Assessment with the Use of NATEM Assay in Cord Blood Samples.Diagnostics (Basel, Switzerland) · 2024Article
- Neonatal hematological parameters: the translational aspect of developmental hematopoiesis.Annals of hematology · 2023Review
- Changes in Platelet Function in Preterm Newborns with Prematurity Related Morbidities.Children (Basel, Switzerland) · 2022Article
- Editorial: Transfusions in the neonatal period.Frontiers in pediatrics · 2022Article
- Development of gates to measure the immature platelet fraction in C57BL/6J mice using the Sysmex XN-V series multispecies hematology analyzer.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants.Frontiers in pediatrics · 2021Article
- Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC).Journal of clinical medicine · 2020Review
- Can immature platelet fraction be an early predictor for congenital pneumonia?Turk pediatri arsivi · 2020Article
- Utility of immature platelet fraction in the Sysmex XN-1000V for the differential diagnosis of central and peripheral thrombocytopenia in dogs and cats.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe immature platelet fraction (IPF) is a laboratory measurement analogous to the reticulocyte count, but reflecting the thrombopoietic state. Similar to a reticulocyte count, it can be expressed as a percent (IPF%=percent of platelets that are immature) or as an absolute number per μl blood; the immature platelet count (IPC=IPF% × platelets per μl of blood). STUDY
designUsing a retrospective analysis of de-identified data from non-thrombocytopenic neonates, we created reference intervals for IPF% and IPC. We then tested the value of these measurements for categorizing thrombocytopenic neonates.
resultsNew charts display reference intervals for IPF% and IPC on the day of birth according to gestational age, and during the first 90 days after birth. Neonates with hyporegenerative varieties of thrombocytopenias (syndromes, small for gestational age, birth asphyxia) had lower IPF% and IPC than did neonates with consumptive thrombocytopenias (immune-mediated, infection, disseminated intravascular coagulation, necrotizing enterocolitis; both P<0.0001).
conclusionThe new reference interval charts can be used to recognize abnormal IPFs. The IPF parameters can help clarify the kinetic mechanism responsible for thrombocytopenias in neonates.
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