ArticleScientific reports2017
A tamB homolog is involved in maintenance of cell envelope integrity and stress resistance of Deinococcus radiodurans.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
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- Terrabacteria: redefining bacterial envelope diversity, biogenesis and evolution.Nature reviews. Microbiology · 2025Review
- Surface Display of Multiple Metal-Binding Domains inInternational journal of molecular sciences · 2024Article
- Redundant essentiality of AsmA-like proteins inmSphere · 2024Article
- A conserved C-terminal domain of TamB interacts with multiple BamA POTRA domains in Borreliella burgdorferi.PloS one · 2024Article
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- Comparative genomics ofFrontiers in microbiology · 2024Article
- Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against HBiological procedures online · 2023Article
- A Novel Glycoside Hydrolase DogH Utilizing Soluble Starch to Maltose Improve Osmotic Tolerance inInternational journal of molecular sciences · 2023Article
- The structured organization ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Distinct lipid membrane interaction and uptake of differentially charged nanoplastics in bacteria.Journal of nanobiotechnology · 2022Article
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- Tolerance engineering in Deinococcus geothermalis by heterologous efflux pumps.Scientific reports · 2021Article
- Ionizing Radiation-induced Proteomic Oxidation inMolecular & cellular proteomics : MCP · 2020Article
- Recent advances in the understanding of trimeric autotransporter adhesins.Medical microbiology and immunology · 2020Review
- MaizeThe Journal of cell biology · 2019Article
- Proteome profiling of Pseudomonas aeruginosa PAO1 identifies novel responders to copper stress.BMC microbiology · 2019Article
- MapB, the Brucella suis TamB homologue, is involved in cell envelope biogenesis, cell division and virulence.Scientific reports · 2019Article
- Amino Acid-Dependent Alterations in Cell Wall and Cell Morphology ofFrontiers in microbiology · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The translocation and assembly module (TAM) in bacteria consists of TamA and TamB that form a complex to control the transport and secretion of outer membrane proteins. Herein, we demonstrated that the DR_1462-DR_1461-DR_1460 gene loci on chromosome 1 of Deinococcus radiodurans, which lacks tamA homologs, is a tamB homolog (DR_146T) with two tamB motifs and a DUF490 motif. Mutation of DR_146T resulted in cell envelope peeling and a decrease in resistance to shear stress and osmotic pressure, as well as an increase in oxidative stress resistance, consistent with the phenotype of a surface layer (S-layer) protein SlpA (DR_2577) mutant, demonstrating the involvement of DR_146T in maintenance of cell envelope integrity. The 123 kDa SlpA was absent and only its fragments were present in the cell envelope of DR_146T mutant, suggesting that DR_146T might be involved in maintenance of the S-layer. A mutant lacking the DUF490 motif displayed only a slight alteration in phenotype compared with the wild type, suggesting DUF490 is less important than tamB motif for the function of DR_146T. These findings enhance our understanding of the properties of the multilayered envelope in extremophilic D. radiodurans, as well as the diversity and functions of TAMs in bacteria.
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