ArticleScientific reports2017
Genetic architecture of bone quality variation in layer chickens revealed by a genome-wide association study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Meta-analysis of genome-wide association studies for loin muscle area and loin muscle depth in two Duroc pig populations.PloS one · 2019Pooled it
- The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch.Ecology and evolution · 2026Article
- Genetics of digital phenotypes of keel bone in layer chickens and correlations with keel bone fractures and deviations.Genetics, selection, evolution : GSE · 2025Article
- Genetic and Environmental Factors Contributing to the Pathogenesis of Vertebral Osteomyelitis Caused byAnimals : an open access journal from MDPI · 2025Review
- Gut-X Axis and Its Role in Poultry Bone Health: A Review.Microorganisms · 2025Review
- Understanding the Causes of Keel Bone Damage and Its Effects on the Welfare of Laying Hens.Animals : an open access journal from MDPI · 2024Review
- Genome-wide association study for bone quality of ducks during the laying period.Poultry science · 2024Article
- Genetic architecture of body weight, carcass, and internal organs traits of Ghanaian local chickens.Frontiers in genetics · 2024Article
- Article
- Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems.G3 (Bethesda, Md.) · 2023Article
- Study of selected genes of Wnt signaling pathway in relation to the parameters in the bone tissue of the laying hens.Saudi journal of biological sciences · 2022Article
- Bone and eggshell quality throughout an extended laying cycle in three strains of layers spanning 50 years of selection.Poultry science · 2022Article
- Untargeted metabolomics reveals the effect of rearing systems on bone quality parameters in chickens.Frontiers in genetics · 2022Article
- Genetic Parameter Estimation and Whole Sequencing Analysis of the Genetic Architecture of Chicken Keel Bending.Frontiers in genetics · 2022Article
- Article
- Dietary Soybean Oil Supplementation Affects Keel Bone Characters and Daily Feed Intake but Not Egg Production and Quality in Laying Hens Housed in Furnished Cages.Frontiers in veterinary science · 2021Article
- Haplotype-based genome-wide association studies for carcass and growth traits in chicken.Poultry science · 2020Article
- Genome-wide association studies targeting the yield of extraembryonic fluid and production traits in Russian White chickens.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal problems in layer chickens are gaining attention due to animal welfare and economic losses in the egg industry. The genetic improvement of bone traits has been proposed as a potential solution to these issues; however, genetic architecture is not well understood. We conducted a genome-wide association study (GWAS) on bone quality using a sample of 1534 hens genotyped with a 600 K Chicken Genotyping Array. Using a linear mixed model approach, a novel locus close to GSG1L, associated with femur bone mineral density (BMD), was uncovered in this study. In addition, nine SNPs in genes were associated with bone quality. Three of these genes, RANKL, ADAMTS and SOST, were known to be associated with osteoporosis in humans, which makes them good candidate genes for osteoporosis in chickens. Genomic partitioning analysis supports the fact that common variants contribute to the variations of bone quality. We have identified several strong candidate genes and genomic regions associated with bone traits measured in end-of-lay cage layers, which accounted for 1.3-7.7% of the phenotypic variance. These SNPs could provide the relevant information to help elucidate which genes affect bone quality in chicken.
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