Evidence map›Paper›PMID 28383479›Full record

ArticleInternational journal of molecular sciences2017

SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma.

Yaxi Wang, Tingyi Sun, Haimei Sun, Shu Yang, Dandan Li, Deshan Zhou

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yaxi WangDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. wangyaxi1@sina.com.
Tingyi SunDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. styj211@ccmu.edu.cn.
Haimei SunDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. haimei@ccmu.edu.cn.
Shu YangDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. sheilayslamb@aliyun.com.
Dandan LiDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. lidan0135@sina.com.
Deshan ZhouDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. zhouds08@ccmu.edu.cn.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Claudin-3 is a major protein of tight junctions (TJs) in the intestinal epithelium and is critical for maintaining cell-cell adhesion, barrier function, and epithelium polarity. Recent studies have shown high claudin-3 levels in several solid tumors, but the regulation mechanism of claudin-3 expression remains poorly understood. In the present study, colorectal cancer (CRC) tissues, HT-29 and DLD-1 CRC cell lines, CRC murine model (C57BL/6 mice) and

Indexed as

MAP Kinase Signaling SystemAnimalsCell Line, TumorClaudin-3Colorectal NeoplasmsGene Expression Regulation, NeoplasticHT29 CellsHumansIntestinal MucosaMiceNeoplasm TransplantationProto-Oncogene Proteins c-kitStem Cell FactorTranscription Factor AP-1Claudin-3Proto-Oncogene Proteins c-kitStem Cell FactorTranscription Factor AP-1activator protein-1c-Jun N-terminal kinasec-kitclaudin-3claudinscolorectal cancer

Identifiers

PMID28383479
PMCPMC5412349
OpenAlexW2604816142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.