Evidence map›Paper›PMID 28383204›Full record

ArticleEuropean journal of immunology2017

Monocytic myeloid-derived suppressor cells regulate T-cell responses against vaccinia virus.

Carl Fortin, Yiping Yang, Xiaopei Huang

Open access · bronzeAbstract read
In one paragraph

Article in European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Japanese Kampo Medicine Juzentaihoto Improves Antiviral Cellular Immunity in Tumour-Bearing Hosts.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Carl FortinDivision of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Yiping YangDivision of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-1291-7460
Xiaopei HuangDivision of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Duke Medical Center · US

Funding

Novel Strategies for Cancer Immunotherapy in Stem Cell TransplantR01CA136934 · NCI · OHIO STATE UNIVERSITY · PI YANG, YIPING · 2009 to 2018
$3.4M
T Memory Stem Cells in CancerR01CA193167 · NCI · OHIO STATE UNIVERSITY · PI YANG, YIPING · 2016 to 2020
$2.2M
Role of inflammation in cancer progressionR21CA186973 · NCI · DUKE UNIVERSITY · PI YANG, YIPING · 2014 to 2015
$378k
NCI NIH HHS R01 CA136934NCI NIH HHS R01 CA193167NCI NIH HHS R21 CA186973
6 · The paper itself

Abstract

Vaccinia virus (VV) can potently activate NK- and T-cell responses, leading to efficient viral control and generation of long-lasting protective immunity. However, immune responses against viral infections are often tightly controlled to avoid collateral damage and systemic inflammation. We have previously shown that granulocytic myeloid-derived suppressor cells (g-MDSCs) can suppress the NK-cell response to VV infection. It remains unknown what regulates T-cell responses to VV infection in vivo. In this study, we first showed that monocytic MDSCs (m-MDSCs), but not g-MDSCs, from VV-infected mice could directly suppress CD4

Indexed as

Lymphocyte ActivationAdoptive TransferAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesInterferon-gammaKiller Cells, NaturalMiceMice, Inbred C57BLMonocytesMyeloid-Derived Suppressor CellsNitric OxideNitric Oxide Synthase Type IIReceptors, CCR2VacciniaVaccinia virusCcr2 protein, mouseInterferon-gammaNitric OxideNitric Oxide Synthase Type IINos2 protein, mouseReceptors, CCR2Immune regulationMonocytesT cells

Identifiers

PMID28383204
PMCPMC5544943
OpenAlexW2604135329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.