ArticleEuropean journal of immunology2017
Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans.
Article in European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.Nature medicine · 2021Trial
- Ebola virus glycoprotein stimulates IL-18-dependent natural killer cell responses.The Journal of clinical investigation · 2020Trial
- Dynamic Changes in Natural Killer Cell Subset Frequencies in the Absence of Cytomegalovirus Infection.Frontiers in immunology · 2019Trial
- Elephant in the room: natural killer cells don't forget HIV either.Current opinion in HIV and AIDS · 2025Review
- Autophagy and Inflammation: Regulatory Roles in Viral Infections.Biomolecules · 2023Review
- NK Cell Subset Redistribution and Antibody Dependent Activation after Ebola Vaccination in Africans.Vaccines · 2022Article
- CMV-associated T cell and NK cell terminal differentiation does not affect immunogenicity of ChAdOx1 vaccination.JCI insight · 2022Article
- Impaired intratumoral natural killer cell function in head and neck carcinoma.Frontiers in immunology · 2022Article
- Antibody-Dependent Natural Killer Cell Activation After Ebola Vaccination.The Journal of infectious diseases · 2021Article
- Virus-specific NK cell memory.The Journal of experimental medicine · 2021Review
- Landscape of natural killer cell activity in head and neck squamous cell carcinoma.Journal for immunotherapy of cancer · 2020Review
- Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV).International journal of molecular sciences · 2020Review
- Review
- Targeting Natural Killer Cells for Improved Immunity and Control of the Adaptive Immune Response.Frontiers in cellular and infection microbiology · 2020Review
- Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses toFrontiers in immunology · 2020Article
- CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML.Blood advances · 2019Article
- Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and NK Cell Function.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.European journal of immunology · 2019Article
- Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Vaccinating for natural killer cell effector functions.Clinical & translational immunology · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Human cytomegalovirus (HCMV) infection drives the phenotypic and functional differentiation of NK cells, thereby influencing the responses of these cells after vaccination. NK cell functional differentiation is particularly advanced in African populations with universal exposure to HCMV. To investigate the impact of advanced differentiation on vaccine-induced responses, we studied NK-cell function before and after vaccination with Trivalent Influenza Vaccine (TIV) or diphtheria, tetanus, pertussis, inactivated poliovirus vaccine (DTPiP) in Africans with universal, lifelong HCMV exposure. In contrast to populations with lower prevalence of HCMV infection, no significant enhancement of NK-cell responses (IFN-γ, CD107a, CD25) occurred after in vitro re-stimulation of post-vaccination NK cells with TIV or DTPiP antigens compared to pre-vaccination baseline cells. However, both vaccinations resulted in higher frequencies of NK cells producing IFN-γ in response to exogenous IL-12 with IL-18, which persisted for up to 6 months. Enhanced cytokine responsiveness was restricted to less differentiated NK cells, with increased frequencies of IFN-γ
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.