ArticleScientific reports2017
Survival benefit of surgery to patients with esophageal squamous cell carcinoma.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Video-assisted mediastinoscopic and laparoscopic transhiatal esophagectomy for esophageal cancer.Surgical endoscopy · 2022Trial
- Prognostic Value of Dynamic Lactate Dehydrogenase Trends in Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma: Retrospective Cohort Study.JMIR cancer · 2026Article
- Gender, racial, and socioeconomic disparities in the management and survival of patients with locally advanced esophageal cancer: a SEER-based study.Surgical endoscopy · 2025Article
- Comparison of Outcomes After McKeown and Ivor Lewis Esophagectomy for Lower Third Esophageal Cancer.Indian journal of surgical oncology · 2025Article
- Neoadjuvant and adjuvant therapy in esophageal cancer.Journal of gastrointestinal oncology · 2023Review
- Long-term survival outcomes associated with robotic-assisted minimally invasive esophagectomy (RAMIE) for esophageal cancer.Surgical endoscopy · 2023Article
- Determinants of survival outcomes among esophageal cancer patients at a national referral hospital in Kenya.Chronic diseases and translational medicine · 2023Article
- SOX2OT lncRNA Inhibition Suppresses the Stemness Characteristics of Esophageal Tumorspheres.Non-coding RNA · 2022Article
- How to distinguish thoracic and cervical lymph nodes during minimally invasive esophagectomy.Thoracic cancer · 2022Article
- Short- (30-90 days) and mid-term (1-3 years) outcomes and prognostic factors of patients with esophageal cancer undergoing surgical treatments.World journal of clinical cases · 2022Article
- Sex differences in esophageal cancer overall and by histological subtype.Scientific reports · 2022Article
- Role of Nutritional Status in the Treatment Outcome for Esophageal Squamous Cell Carcinoma.Nutrients · 2021Article
- Racial Disparities in Rates of Surgery for Esophageal Cancer: a Study from the National Cancer Database.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Post-radiation circulating tumor DNA as a prognostic factor in locally advanced esophageal squamous cell carcinoma.Oncology letters · 2021Article
- Alteration of plasma metabolites associated with chemoradiosensitivity in esophageal squamous cell carcinoma via untargeted metabolomics approach.BMC cancer · 2020Article
- Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma.World journal of surgical oncology · 2020Article
- Lymph Node and Bone Marrow Micrometastases Define the Prognosis of Patients with pN0 Esophageal Cancer.Cancers · 2020Article
- Survival and prognostic factors of patients with esophageal fistula in advanced esophageal squamous cell carcinoma.Bioscience reports · 2020Article
- Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2.International journal of biological sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess if surgery provided survival benefit to patients with esophageal squamous cell carcinoma (SCC), we performed a retrospective review of 1230 patients who were newly diagnosed with stage T2-T4 esophageal SCC from 2007 to 2014 in our hospital. There were greater than 70% of patients with age under 65 years, and more than 85% were stage T3-T4 at the time of diagnosis. The median survival time was 1.06 year (95% CI 0.99-1.1 yrs). Survival analyses showed that survival time was significantly associated with age, T stage, clinical lymph node involvement and treatment modality (surgery versus definite chemoradiotherapy). Surgery still possessed a powerful impact on overall survival by multivariable analysis. Death risk of patients treated with curative surgery was significantly lower than those with definite chemoradiotherapy. Furthermore, for patients of stage T3N(+) and T4, surgery combined with (neo-)adjuvant treatment were significantly associated with higher survival rate than surgery alone or definite chemoradiotherapy. In conclusion, the patients who undergo surgery were significantly associated longer survival, therefore, curative resection should be considered for esophageal cancer patients who are medically fit for surgery. Moreover, combined with (neo-)adjuvant treatment is recommended for surgically resectable stage T3-T4 esophageal SCC.
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