Observational studyJournal of human hypertension2017
Treatment of primary aldosteronism is associated with a reduction in the severity of obstructive sleep apnoea.
Observational study in Journal of human hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Clinical and Biochemical Features Associated with Coexisting Primary Aldosteronism in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Primary aldosteronism and obstructive sleep apnea in hypertension: interplay, target organ damage, and clinical management.Frontiers in endocrinology · 2026Review
- Obstructive sleep apnea-associated hypertensive disorders in pregnancy: a literature review and clinical management strategies.Reproductive biology and endocrinology : RB&E · 2025Review
- Association of estimated glomerular filtration rate with the incidence of sleep apnea syndrome.Sleep · 2025Article
- Evolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis.Therapeutic advances in chronic disease · 2025Article
- Short-term longitudinal clinical, biochemical, and quality of life outcomes of medical or surgical therapy in unilateral primary aldosteronism.Frontiers in endocrinology · 2025Article
- Endocrine Hypertension: The Urgent Need for Greater Global Awareness.TouchREVIEWS in endocrinology · 2023Review
- Screening for Primary Aldosteronism Among Hypertensive Adults with Obstructive Sleep Apnea: A Retrospective Population-Based Study.American journal of hypertension · 2023Article
- Primary aldosteronism and obstructive sleep apnea: What do we know thus far?Frontiers in endocrinology · 2022Review
- Screening for Primary Aldosteronism is Underutilized in Patients with Obstructive Sleep Apnea.The American journal of medicine · 2022Article
- Primary aldosteronism is highly prevalent in patients with hypertension and moderate to severe obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Eplerenone as a treatment for resistant hypertension in pregnancy.Obstetric medicine · 2021Article
- Cerebro-Cardiovascular Risk, Target Organ Damage, and Treatment Outcomes in Primary Aldosteronism.Frontiers in cardiovascular medicine · 2021Review
- The Role of Aldosterone in OSA and OSA-Related Hypertension.Frontiers in endocrinology · 2021Review
- A pilot study in men to show the effects of postural fluid shifts on the severity of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2020Article
- Hyperaldosteronism: How Current Concepts Are Transforming the Diagnostic and Therapeutic Paradigm.Kidney360 · 2020Review
- Management of primary aldosteronism and mineralocorticoid receptor-associated hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Update in Sleep 2019.American journal of respiratory and critical care medicine · 2020Review
- The 2020 Italian Society of Arterial Hypertension (SIIA) practical guidelines for the management of primary aldosteronism.International Journal of Cardiology. Hypertension · 2020Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnoea (OSA) is known to commonly co-exist with primary aldosteronism (PA), but it is unknown if treatment of PA improves sleep apnoea parameters in these patients. We therefore aimed to determine whether specific medical or surgical treatment of PA improves OSA, as measured by the apnoea-hypopnoea index (AHI). We recruited patients undergoing diagnostic workup for PA if they had symptoms suggestive of OSA. Patients with confirmed PA underwent polysomnography (PSG) at baseline and again at least 3 months after specific treatment for PA. Of 34 patients with PA, 7 (21%) had no evidence of OSA (AHI <5), 9 (26%) had mild (AHI ⩾5 and <15), 8 (24%) moderate (AHI ⩾15 and <30) and 10 (29%) severe OSA (AHI ⩾30). Body mass index tertile, neck circumference and 24 h urinary sodium correlated with the AHI. Twenty patients had repeat PSG performed after treatment for PA (mineralocorticoid receptor antagonists in 13 with bilateral PA and adrenalectomy in 7 with unilateral PA). In this group the median (s.d.) AHI reduced from 22.5 (14.7) to 12.3 (12.1) (P=0.02). Neck circumference reduced with PA treatment (41.6 vs 41.2 cm, P=0.012). OSA is common in patients with primary aldosteronism and may improve with specific therapy for this disease. Aldosterone and sodium-mediated fluid retention in the upper airways and neck region may be a potential mechanism for this relationship.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.