ArticleScientific reports2017
On/off-switchable LSPR nano-immunoassay for troponin-T.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A Plasmonic Nanoledge Array Sensor for Selective Detection of Cardiovascular Disease Biomarkers in Human Whole Blood.ACS applied nano materials · 2024Article
- pH regulated lactose inspired fabrication of zinc oxide nanoparticles for insulin sensing by LSPR absorption.Heliyon · 2023Article
- Fabrication of a Molecularly Imprinted Nano-Interface-Based Electrochemical Biosensor for the Detection of CagA Virulence Factors ofBiosensors · 2022Article
- Progress in COVID research and developments during pandemic.View (Beijing, China) · 2022Review
- Spectral image contrast-based flow digital nanoplasmon-metry for ultrasensitive antibody detection.Journal of nanobiotechnology · 2022Article
- The role of antibody-based troponin detection in cardiovascular disease: A critical assessment.Journal of immunological methods · 2021Review
- Recent Advancements in Receptor Layer Engineering for Applications in SPR-Based Immunodiagnostics.Sensors (Basel, Switzerland) · 2021Review
- Nanohybrid-based immunosensor prepared for Helicobacter pylori BabA antigen detection through immobilized antibody assembly with @ PdScientific reports · 2020Article
- Noble Metal-Assisted Surface Plasmon Resonance Immunosensors.Sensors (Basel, Switzerland) · 2020Review
- Highly sensitive immunosensing platform for one-step detection of genetically modified crops.Scientific reports · 2019Article
- Fabrication of Troponin I Biosensor Composed of Multi-Functional DNA Structure/Au Nanocrystal Using Electrochemical and Localized Surface Plasmon Resonance Dual-Detection Method.Nanomaterials (Basel, Switzerland) · 2019Article
- An electrochemical troponin T aptasensor based on the use of a macroporous gold nanostructure.Mikrochimica acta · 2019Article
- Development of the Troponin Detection System Based on the Nanostructure.Micromachines · 2019Review
- Article
- Immunocontrolling Graphene Oxide Catalytic Nanogold Reaction and Its Application to SERS Quantitative Analysis.ACS omega · 2017Article
- Localized surface plasmon resonance-based abscisic acid biosensor using aptamer-functionalized gold nanoparticles.PloS one · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration of immunosensors is a longstanding challenge. We have developed a re-usable troponin-T (TnT) immunoassay based on localised surface plasmon resonance (LSPR) at gold nanorods (GNR). Thermosensitive poly(N-isopropylacrylamide) (PNIPAAM) was functionalised with anti-TnT to control the affinity interaction with TnT. The LSPR was extremely sensitive to the dielectric constant of the surrounding medium as modulated by antigen binding after 20 min incubation at 37 °C. Computational modelling incorporating molecular docking, molecular dynamics and free energy calculations was used to elucidate the interactions between the various subsystems namely, IgG-antibody (c.f., anti-TnT), PNIPAAM and/or TnT. This study demonstrates a remarkable temperature dependent immuno-interaction due to changes in the PNIPAAM secondary structures, i.e., globular and coil, at above or below the lower critical solution temperature (LCST). A series of concentrations of TnT were measured by correlating the λ
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