ArticleThe Australian and New Zealand journal of psychiatry2017
White matter deficits in schizophrenia are global and don't progress with age.
Article in The Australian and New Zealand journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurofilament Light Protein as a Biomarker in Severe Mental Disorders: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- An Exploratory Comparison of Alpha and Beta Network Connectivity Across Four Depression Subtypes.Journal of clinical medicine · 2025Article
- Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls.Molecular psychiatry · 2024Review
- Neurofilament light-chain (NfL) and 18 kDa translocator protein in early psychosis and its putative high-risk.Brain, behavior, & immunity - health · 2024Article
- Predicting aging trajectories of decline in brain volume, cortical thickness and fractional anisotropy in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Heritable anisotropy associated with cognitive impairments among patients with schizophrenia and their non-psychotic relatives in multiplex families.Psychological medicine · 2022Article
- Reduced white matter integrity associated with cognitive deficits in patients with drug-naive first-episode schizophrenia revealed by diffusion tensor imaging.American journal of translational research · 2020Article
- Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia.Frontiers in psychiatry · 2020Review
- Increased white matter metabolic rates in autism spectrum disorder and schizophrenia.Brain imaging and behavior · 2018Article
- Schizophrenia moderates the relationship between white matter integrity and cognition.Schizophrenia research · 2018Article
- Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia.Human brain mapping · 2018Article
- White matter microstructure predicts cognitive training-induced improvements in attention and executive functioning in schizophrenia.Schizophrenia research · 2018Article
- Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia.Brain connectivity · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionDiffusion tensor imaging has revealed differences in all examined white matter tracts in schizophrenia, with a range of explanations for why this may be. The distribution and timing of differences may help explain their origin; however, results are usually dependent on the analytical method. We therefore sought to examine the extent of differences and their relationship with age using two different methods.
methodsA combined voxel-based whole-brain study and a tract-based spatial-statistics study of 104 patients with schizophrenia and 200 matched healthy controls, aged between 17 and 63 years.
resultsFractional anisotropy was reduced throughout the brain in both analyses. The relationship of fractional anisotropy with age differed between patients and controls, with controls showing the gentle fractional anisotropy decline widely noted but patients showing an essentially flat relationship: younger patients had lower fractional anisotropy than controls, but the difference disappeared with age. Mean diffusivity was widely increased in patients.
conclusionReduction in fractional anisotropy and increase in mean diffusivity would be consistent with global disruption in myelination; the relationship with age would suggest this is present already at the onset of their illness, but does not progress.
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