Evidence map›Paper›PMID 28382722›Full record

SynthesisActa paediatrica (Oslo, Norway : 1992)2017

Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes.

Esther Castanys-Muñoz, Kathy Kennedy, Eurídice Castañeda-Gutiérrez, Stewart Forsyth, Keith M Godfrey, Berthold Koletzko, Susan E Ozanne, Ricardo Rueda, Marieke Schoemaker, Eline M van der Beek and 2 more

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
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  8. A Framework for Evaluation of New Processing Technologies in Human Milk Banking.Comprehensive reviews in food science and food safety · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 5 countries.

Esther Castanys-MuñozAbbott Nutrition R&D, University Science Park, Granada, Spain.
Kathy KennedyUCL Great Ormond Street Hospital Institute of Child Health, London, UK.
Eurídice Castañeda-GutiérrezNestlé Research Center, Lausanne, Switzerland.
Stewart ForsythDSM-Martek Division, Dundee, UK.
Keith M GodfreyMRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Berthold KoletzkoLudwig-Maximilians-Universität Munich, Dr. von Hauner Children's Hospital, University of Munich Medical Center, München, Germany.
Susan E OzanneMetabolic Research Laboratories & MRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Ricardo RuedaAbbott Nutrition R&D, Granada, Spain.
Marieke SchoemakerMead Johnson Pediatric Nutrition Institute, Nijmegen, The Netherlands.
Eline M van der BeekNutricia Research, Danone Nutricia Early Life Nutrition, Utrecht, The Netherlands.
Stef van BuurenNetherlands Organisation for Applied Scientific Research TNO, Leiden, The Netherlands.
Ken K OngMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Abbott (Spain) · ESGreat Ormond Street Hospital · GBLudwig-Maximilians-Universität München · DENestlé (Switzerland) · CHNetherlands Organisation for Applied Scientific Research · NLNIHR Southampton Biomedical Research Centre · GBNutricia Research (Netherlands) · NLUniversity of Cambridge · GBUniversity of Dundee · GBWellcome/MRC Institute of Metabolic Science · GB

Funding

British Heart Foundation PG/14/33/30827British Heart Foundation RG/15/17/31749Medical Research Council MC_U147574222Medical Research Council MC_U147574226Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12012/4Medical Research Council MC_UU_12015/2
6 · The paper itself

Abstract

We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affect neurodevelopment and metabolic outcomes in term-born small-for-gestational-age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure (BP), but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and BP.

conclusionFew intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants.

Indexed as

Child DevelopmentAdiposityBlood PressureCognitionHumansInfant, NewbornInfant, Small for Gestational AgeLipidsWeight GainLipidsAdiposityInsulin resistanceNeurodevelopmentPostnatal growthSmall for gestational age

Identifiers

PMID28382722
PMCPMC5507303
OpenAlexW2605287062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.