ArticleMagnetic resonance in medicine2018
Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 24 citations in OpenAlex.
- Cardiovascular Magnetic Resonance Elastography: Current Evidence, Challenges, and Future Perspectives.Diagnostics (Basel, Switzerland) · 2026Review
- Reproducibility of 3.0 T single-frequency cardiac MR elastography for quantification of left ventricular myocardial stiffness.Radiology advances · 2026Article
- Changes in myocardial elasticity derived from in-vivo cardiac MRI in a swine model of ischemic heart failure.Scientific reports · 2026Article
- Advances in Non-Invasive Myocardial Stiffness Assessment and Clinical Applications in Hypertrophic Cardiomyopathy.Reviews in cardiovascular medicine · 2026Review
- Distinguishing shear and tensile myocardial wall stiffness using ex vivo anisotropic Magnetic Resonance Elastography.Acta biomaterialia · 2025Article
- Rheological properties of porcine organs: measurements and fractional viscoelastic model.Frontiers in bioengineering and biotechnology · 2024Article
- Validating MRI-Derived Myocardial Stiffness Estimates Using In Vitro Synthetic Heart Models.Annals of biomedical engineering · 2023Article
- Don't go breakin' my heart: cardioprotective alterations to the mechanical and structural properties of reperfused myocardium during post-infarction inflammation.Biophysical reviews · 2023Review
- Contractile Adaptation of the Left Ventricle Post-myocardial Infarction: Predictions by Rodent-Specific Computational Modeling.Annals of biomedical engineering · 2023Article
- Characterization of main pulmonary artery and valve annulus region of piglets using echocardiography, uniaxial tensile testing, and a novel non-destructive technique.Frontiers in cardiovascular medicine · 2022Article
- Passive myocardial mechanical properties: meaning, measurement, models.Biophysical reviews · 2021Review
- Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity.Scientific reports · 2021Article
- Microenvironment Stiffness Amplifies Post-ischemia Heart Regeneration in Response to Exogenous Extracellular Matrix Proteins in Neonatal Mice.Frontiers in cardiovascular medicine · 2021Article
- Microenvironment stiffness requires decellularized cardiac extracellular matrix to promote heart regeneration in the neonatal mouse heart.Acta biomaterialia · 2020Article
- Inflammatory Cytokines Alter Mesenchymal Stem Cell Mechanosensing and Adhesion on Stiffened Infarct Heart Tissue After Myocardial Infarction.Frontiers in cell and developmental biology · 2020Article
- Non-invasive Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force Impulse Imaging.Ultrasound in medicine & biology · 2019Article
- Acellular Extracellular Matrix Bioscaffolds for Cardiac Repair and Regeneration.Frontiers in cell and developmental biology · 2019Review
- Regional and temporal changes in left ventricular strain and stiffness in a porcine model of myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2018Article
- Cardiovascular magnetic resonance elastography: A review.NMR in biomedicine · 2018Review
- Cardiac MR elastography using reduced-FOV, single-shot, spin-echo EPI.Magnetic resonance in medicine · 2018Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing.
methodsMyocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium.
resultsMyocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01).
conclusionsThese results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361-369, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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