Evidence map›Paper›PMID 28382551›Full record

Trial reportEuropean journal of applied physiology2017

High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly men.

Astrid Kamilla Stunes, Unni Syversen, Sveinung Berntsen, Gøran Paulsen, Tonje H Stea, Ken J Hetlelid, Hilde Lohne-Seiler, Mats Peder Mosti, Thomas Bjørnsen, Truls Raastad and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. The Impact of Environmental Chemicals on the Gut Microbiome.Toxicological sciences : an official journal of the Society of Toxicology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Astrid Kamilla StunesDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, (NTNU), Trondheim, Norway. kamilla.stunes@ntnu.no.ORCID http://orcid.org/0000-0003-1074-5199
Unni SyversenDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, (NTNU), Trondheim, Norway.
Sveinung BerntsenDepartment of Public Health, Sport and Nutrition, University of Agder, Kristiansand, Norway.
Gøran PaulsenDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Tonje H SteaDepartment of Public Health, Sport and Nutrition, University of Agder, Kristiansand, Norway.
Ken J HetlelidDepartment of Public Health, Sport and Nutrition, University of Agder, Kristiansand, Norway.
Hilde Lohne-SeilerDepartment of Public Health, Sport and Nutrition, University of Agder, Kristiansand, Norway.
Mats Peder MostiDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, (NTNU), Trondheim, Norway.
Thomas BjørnsenDepartment of Public Health, Sport and Nutrition, University of Agder, Kristiansand, Norway.
Truls RaastadDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Glenn HaugebergDepartment of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeResistance training is beneficial for maintaining bone mass. We aimed to investigate the skeletal effects of high doses of antioxidants [vitamin C + E (α-tocopherol)] supplementation during 12-week supervised strength training in healthy, elderly men

methodsDesign: double-blinded randomized placebo-controlled study. Participants followed a supervised, undulating periodic exercise program with weekly adjusted load: 3 sessions/week and 3-15 repetitions maximum (RM) sets/exercise. The control group (CG, n = 17, 67 ± 5 years) received placebo and the antioxidant group (AO, n = 16, 70 ± 7 years) 1000 mg vitamin C + 235 mg vitamin E, daily. Areal bone mineral density (aBMD) at whole body, lumbar spine (L1-L4), total hip, and femoral neck were measured by dual energy X-ray absorptiometry and muscle strength by 1RM. Serum analyses of bone-related factors and adipokines were performed.

resultsIn the CG, total hip aBMD increased by 1.0% (CI: 0.3-1.7) versus pretest and lumbar spine aBMD increased by 0.9% (CI: -0.2 to 2.0) compared to the AO. In the CG, there was an increase in serum concentrations of insulin-like growth factor 1 [+27.3% (CI: -0.3 to 54.9)] and leptin [+31.2% (CI: 9.8-52.6)) versus pretest, and a decrease in sclerostin [-9.9% (CI: 4.4-15.3)] versus pretest and versus AO. Serum bone formation markers P1NP and osteocalcin increased in both groups, while the bone resorption marker CTX-1 remained unchanged.

conclusionHigh doses of antioxidant supplementations may constrain the favorable skeletal benefits of 12 weeks of resistance exercise in healthy elderly men.

Indexed as

Bone DensityResistance TrainingAgedAscorbic AcidBone and BonesBone DevelopmentDouble-Blind MethodHumansMaleMiddle AgedVitamin EVitaminsAscorbic AcidVitamin EVitaminsBone mineral densityElderly menStrength trainingVitamin C + E

Identifiers

PMID28382551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.