ReviewInternational journal of cardiology. Heart & vasculature2017
Electrophysiological mechanisms of long and short QT syndromes.
Review in International journal of cardiology. Heart & vasculature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 85 citations in OpenAlex.
- QTc measurement using Apple Watch electrocardiogram in congenital long QT syndrome.European heart journal. Digital health · 2026Article
- Nedaplatin induced QT prolongation with polymorphic ventricular tachyarrhythmia: clinical experience and review of literature.Cardio-oncology (London, England) · 2026Article
- Dynamical cross-correlations between RR and QT intervals in long-term electrocardiogram recordings.Scientific reports · 2026Article
- Aging-Induced QT Prolongation as a Potential Contributor to Longevity.Journal of cardiovascular development and disease · 2026Review
- Low serum zinc levels and risk of incident atrial fibrillation/flutter: a multi-institutional study.Frontiers in nutrition · 2026Article
- A Characteristic Electrocardiographic Manifestation Suggests Hypercalcemia.Diagnostics (Basel, Switzerland) · 2025Article
- QT interval prolongation: clinical assessment, risk factors and quantitative pharmacological considerations.Journal of pharmacokinetics and pharmacodynamics · 2025Review
- Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy.Nature communications · 2025Article
- Cardiac NADNature cardiovascular research · 2024Article
- Arrhythmogenic Ventricular Remodeling by Next-Generation Bruton's Tyrosine Kinase Inhibitor Acalabrutinib.International journal of molecular sciences · 2024Article
- Effect of Empagliflozin Treatment on Ventricular Repolarization Parameters.Reviews in cardiovascular medicine · 2024Article
- Bacterial toxins and heart function: heat-labileBiophysical reviews · 2023Article
- Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.Scientific reports · 2023Article
- Prognostic Value of Tpeak-Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2023Article
- The Antidepressant Paroxetine Reduces the Cardiac Sodium Current.International journal of molecular sciences · 2023Article
- Primary Hyperparathyroidism Is Associated With Shorter QTc Intervals, but Not Arrhythmia.The Journal of clinical endocrinology and metabolism · 2022Article
- Clinical Genetics of Inherited Arrhythmogenic Disease in the Pediatric Population.Biomedicines · 2022Review
- A novel variant inHeartRhythm case reports · 2021Article
- Article
- Paediatric/young versus adult patients with long QT syndrome.Open heart · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The QT interval on the human electrocardiogram is normally in the order of 450 ms, and reflects the summated durations of action potential (AP) depolarization and repolarization of ventricular myocytes. Both prolongation and shortening in the QT interval have been associated with ventricular tachy-arrhythmias, which predispose affected individuals to sudden cardiac death. In this article, the molecular determinants of the AP duration and the causes of long and short QT syndromes (LQTS and SQTS) are explored. This is followed by a review of the recent advances on their arrhythmogenic mechanisms involving reentry and/or triggered activity based on experiments conducted in mouse models. Established and novel clinical risk markers based on the QT interval for the prediction of arrhythmic risk and cardiovascular mortality are presented here. It is concluded by a discussion on strategies for the future rational design of anti-arrhythmic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.