ReviewCureus2017
The Pathophysiology of Perceived Social Isolation: Effects on Health and Mortality.
Review in Cureus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06138301 (Digital Interventions for Social isOLation In youThs And theIR familiEs), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Digital Interventions for Social isOLation In youThs And theIR familiEs
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- The Associations Between Digital Exclusion and Physical or Cognitive Function in Middle-Aged and Older Adults: Systematic Review and Meta-Analysis.JMIR aging · 2026Pooled it
- Evolution of body image across treatment eras: a systematic review in young people and adults living with cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Comparison of the 18-item and 6-item Lubben Social Network Scales with community-dwelling older adults in Mongolia.PloS one · 2019Trial
- Development and validation of the Korea University Social Isolation Scale.BMC public health · 2026Article
- Associations between migrant status, social isolation, and loneliness among older adults in India.BMC geriatrics · 2026Article
- The experiences of doctors in Lesotho during the COVID-19 pandemic: A qualitative study.PloS one · 2026Article
- Article
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Factors associated with the use of psychotropic drugs by students at a brazilian public university.Revista peruana de medicina experimental y salud publica · 2025Article
- Exploring Social Support Strategies and Socio-Cultural Factors Influencing Social Isolation and Loneliness: The Role of Digital Literacy.Healthcare (Basel, Switzerland) · 2024Article
- The impact of social isolation policies during COVID-19 on suburban mothers and pregnant women with opioid use disorder.Women & health · 2024Article
- Digital exclusion and cognitive impairment in older people: findings from five longitudinal studies.BMC geriatrics · 2024Article
- Associations between Social Contact, Sleep and Dietary Patterns among Children: A Cross-Sectional Study.Foods (Basel, Switzerland) · 2024Article
- Developing a brief telematic cognitive behavioral therapy for the treatment of social isolation in young adults.Frontiers in psychology · 2024Article
- Promoting Access in a Mexican-American Museum during the Pandemic: Online Community Events and Robots.The international journal of the inclusive museum · 2023Article
- Relationship of sleep-quality and social-anxiety in patients with breast cancer: a network analysis.BMC psychiatry · 2023Article
- High social risk and mortality. A prospective study in community-dwelling older adults living in a rural Ecuadorian village.Preventive medicine reports · 2023Article
- [Offers to prevent social isolation and loneliness in older people living in rural areas].Pravention und Gesundheitsforderung · 2023Article
- Edaravone Improved Behavioral Abnormalities, Alleviated Oxidative Stress Inflammation, and Metabolic Homeostasis Pathways in Depression.Depression and anxiety · 2023Article
- Loneliness in Posttraumatic Stress Disorder: A Neglected Factor in Accelerated Aging?Journal of ageing and longevity · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perceived social isolation (PSI) is a deficit in normal human social interaction, which has been associated with negative health outcomes. However, the precise mechanisms through which PSI influences human health are not fully known. This review aims at bringing out what is known about these pathways through which social isolation affects human health. We searched PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), Psychological Information Database (PsycINFO), and Cochrane Library in addition to secondary references from primary journal articles for the most relevant and recent information concerning the research topic. The keywords used were perceived social isolation, loneliness, health outcomes, cardiovascular effects, neuroendocrine effects, depression, and cognitive decline, in animal and human populations. There are clear linkages between PSI and the cardiovascular system, neuroendocrine system, and cognitive functioning. PSI also leads to depression, cognitive decline, and sleep problems. The mechanisms through which PSI causes these effects are neural, hormonal, genetic, emotional, and behavioral. The effects of PSI on health are both direct and indirect. There is a complex interconnected network of pathways through which PSI negatively influences health. These hypothetical pathways using which the effects of PSI have been explained form the base on which further analyses can be carried out.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.