Evidence map›Paper›PMID 28382148›Full record

ArticleJournal of Cancer2017

NR1H3 Expression is a Prognostic Factor of Overall Survival for Patients with Muscle-Invasive Bladder Cancer.

Junlong Wu, Fangning Wan, Haoyue Sheng, Guohai Shi, Yijun Shen, Guowen Lin, Bo Dai, Yiping Zhu, Dingwei Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Junlong WuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Fangning WanDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Haoyue ShengDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Guohai ShiDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Yijun ShenDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Guowen LinDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Bo DaiDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Yiping ZhuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Dingwei YeDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNuclear receptors (NRs) are a class of transcription factors that regulate many cellular functions through manipulation of gene expression and also play important roles in tumorigenesis, proliferation, progression and prognosis in various kinds of cancers according to recent studies. This work aimed to determine the predictive ability of NRs in muscle-invasive bladder cancer (MIBC). PATIENTS AND

methodsA total of 308 MIBC patients with complete clinicopathological and RNASeq data from The Cancer Genome Atlas (TCGA) cohort were collected for filtration. Genes showed clear correlations with overall survival (OS) and recurrence free survival (RFS) were further validated in 123 MIBC patients recruited consecutively from 2008 to 2012 in Fudan University Shanghai Cancer Center (FUSCC) cohort. Cox proportional hazards regression model and Kaplan-Meier plot were used to assess the relative factors.

resultsIn TCGA cohort, we found that high NR1H3 (HR=0.779, 95% CI: 0.634 - 0.957), NR2C1 (HR=0.673, 95% CI: 0.458 - 0.989) and NR2F6 (HR=0.750, 95% CI: 0.574 - 0.980) expressions were independent factors of favorable OS, while only low NR1H3 (log-rank test, P=0.0076) and NR2F6 (log-rank test, P=0.0395) expressions had the ability to predict poor prognosis for RFS. Further, in FUSCC validating cohort, we confirmed that low NR1H3 expression level was independent factor of poor OS (HR=1.295, 95% CI: 1.064 - 1.576) and it had the ability to predict poor RFS (log-rank test, P=0.0059).

conclusionsLow NR1H3 expression level is an independent prognostic factor of poor OS, and can also predict worse RFS in MIBC patients. Our "TCGA filtrating and local database validating" model can help reveal more prognostic biomarkers and cast a new light in understanding certain gene function in MIBC.

Indexed as

muscle-invasive bladder cancerNR1H3Nuclear receptoroverall survival

Identifiers

PMID28382148
PMCPMC5381174
OpenAlexW2596040508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.