The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

1. KRAS signaling networks, mutational heterogeneity, and emerging therapeutic strategies for cancer treatment.Biomarker research · 2026
   Review
2. Increase of intracellular ZnScientific reports · 2025
   Article
3. Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.Infection and immunity · 2024
   Article
4. Phospholipase Family Enzymes in Lung Cancer: Looking for Novel Therapeutic Approaches.Cancers · 2023
   Review
5. Molecular regulation of PLCβ signaling.Methods in enzymology · 2023
   Review
6. Inhibition of the Phospholipase Cε-c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties.International journal of molecular sciences · 2022
   Article
7. Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma.Cancers · 2022
   Article
8. Dissecting the Mechanism of Action of Spiperone-A Candidate for Drug Repurposing for Colorectal Cancer.Cancers · 2022
   Article
9. A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation.Molecular cancer · 2021
   Article
10. PLCε1 suppresses tumor growth by regulating murine T cell mobilization.Clinical and experimental immunology · 2020
    Article
11. PLCε knockdown prevents serine/glycine metabolism and proliferation of prostate cancer by suppressing YAP.American journal of cancer research · 2020
    Article
12. Phospholipase C.Advances in experimental medicine and biology · 2020
    Review
13. Phospholipase C (PLC)ε Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
14. Resolving gastric cancer aetiology: an update in genetic predisposition.The lancet. Gastroenterology & hepatology · 2018
    Review
15. The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response.Journal of immunology research · 2018
    Review
16. Phospholipase C ε-1 gene polymorphisms and prognosis of esophageal cancer patients from a high-incidence region in northern China.Molecular and clinical oncology · 2018
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 3 institutions in 2 countries.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as