ReviewTherapeutic advances in musculoskeletal disease2017
Analytical considerations for the biochemical assessment of vitamin D status.
Review in Therapeutic advances in musculoskeletal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Effect of 12-Week BMI-Based Vitamin DInternational journal of molecular sciences · 2023Trial
- Association of 25(OH)D serum level with biological aging: A Cross-Sectional Study of 2007-2016 NHANES surveys.PloS one · 2025Article
- Laboratory considerations in the assessment of 25-hydroxyvitamin D in pregnant women by automated immunoassays.Practical laboratory medicine · 2024Article
- The Edge Effect in High-Throughput Proteomics: A Cautionary Tale.Journal of the American Society for Mass Spectrometry · 2023Article
- Mass spectrometry-based chemical mapping and profiling toward molecular understanding of diseases in precision medicine.Chemical science · 2021Review
- A LC-MS method for 25-hydroxy-vitamin D3 measurements from dried blood spots for an epidemiological survey in India.Scientific reports · 2020Article
- Vitamin D Metabolism and Profiling in Veterinary Species.Metabolites · 2020Review
- Chronic kidney disease is a main confounding factor for 25-vitamin D measurement.Jornal brasileiro de nefrologia · 2020Article
- Osteoporosis in South-East Asian Countries.The Clinical biochemist. Reviews · 2020Review
- Higher Vitamin D Levels Are Associated with Better Attentional Functions: Data from the NorCog Register.The journal of nutrition, health & aging · 2019Article
- Vitamin D and associated perinatal-neonatal outcomes among extremely low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge.Frontiers in endocrinology · 2018Review
- Impact of bone disease and pain in thalassemia.Hematology. American Society of Hematology. Education Program · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most widely used and clinically accepted biochemical marker for assessing vitamin D status is the total serum 25-hydroxyvitamin D [25(OH)D] concentration. Despite the analysis of 25(OH)D dating back to the early 1970s, modern analytical techniques still exhibit significant interassay variability due to varying concentrations of other related vitamin D metabolites and sample-to-sample matrix differences. It is important for clinicians requesting 25(OH)D analyses to understand these issues and limitations, and where necessary to confront laboratories for details of analytical methods used. The availability of reference measurement procedures for 25(OH)D based on liquid chromatography and tandem mass spectrometry, whilst not intended for routine clinical sample analysis, should be utilized to improve assay harmonization and reduce interlaboratory variability. Laboratories should also be forthcoming with details of subscriptions to external quality assessment schemes and assay traceability. As well as discussing the reasons for ongoing assay variability for 25(OH)D, this short review will also briefly discuss other assays related to the assessment of vitamin D status, including parathyroid hormone, 24,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D and vitamin D binding proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.