ReviewTherapeutic advances in musculoskeletal disease2017
The role of vitamin D in maintaining bone health in older people.
Review in Therapeutic advances in musculoskeletal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03213886 (A Prospective Randomized Trial Comparing the Effects of 2 Vitamin D Supplementation Regimens in Elderly People After Hip Fracture Surgery), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Randomized Trial Comparing the Effects of 2 Vitamin D Supplementation Regimens in Elderly People After Hip Fracture Surgery
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Efficacy of vitamin D supplementation on depressive symptoms in older patients: a meta-analysis of randomized controlled trials.Frontiers in medicine · 2024Pooled it
- The role of serum levels of vitamin D in children's muscle strength: A systematic review.Clinics (Sao Paulo, Brazil) · 2021Pooled it
- Pooled it
- A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Trial
- Benefits of Two 24-Week Interactive Cognitive-Motor Programs on Body Composition, Lower-Body Strength, and Processing Speed in Community Dwellings at Risk of Falling: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Twelve-Week Daily Consumption ofNutrients · 2020Trial
- Trial
- Lower preoperative vitamin D levels are associated with poor clinical outcomes in elderly patients with osteoporotic vertebral compression fractures after percutaneous vertebroplasty.Frontiers in medicine · 2026Article
- Texture-modified diets in long-term care facilities: assessing adherence to nutrition standards.JAR life · 2026Article
- Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Prognostic impact of preoperative osteopenia in elderly patients with lung cancer.World journal of surgical oncology · 2025Article
- Vitamin D testing in pharmacies: Results of a federal screening campaign.Exploratory research in clinical and social pharmacy · 2025Article
- Article
- Effects of dietary supplements on bone turnover markers in women after menopause: a network meta-analysis.PeerJ · 2025Article
- Association of vitamin D and bisphenol A levels with cardiovascular risk in an elderly Italian population: results from the InCHIANTI study.GeroScience · 2024Article
- Structural diversification of vitamin D using microbial biotransformations.Applied microbiology and biotechnology · 2024Review
- The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases.Frontiers in endocrinology · 2024Article
- Article
- The Prevalence and Determinants of Vitamin D Status among Older Adults: Data from a Longitudinal Aging Study.International journal of preventive medicine · 2023Article
- Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study.Nutrients · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
This review summarises aspects of vitamin D metabolism, the consequences of vitamin D deficiency, and the impact of vitamin D supplementation on musculoskeletal health in older age. With age, changes in vitamin D exposure, cutaneous vitamin D synthesis and behavioural factors (including physical activity, diet and sun exposure) are compounded by changes in calcium and vitamin D pathophysiology with altered calcium absorption, decreased 25-OH vitamin D [25(OH)D] hydroxylation, lower renal fractional calcium reabsorption and a rise in parathyroid hormone. Hypovitaminosis D is common and associated with a risk of osteomalacia, particularly in older adults, where rates of vitamin D deficiency range from 10-66%, depending on the threshold of circulating 25(OH)D used, population studied and season. The relationship between vitamin D status and osteoporosis is less clear. While circulating 25(OH)D has a linear relationship with bone mineral density (BMD) in some epidemiological studies, this is not consistent across all racial groups. The results of randomized controlled trials of vitamin D supplementation on BMD are also inconsistent, and some studies may be less relevant to the older population, as, for example, half of participants in the most robust meta-analysis were aged under 60 years. The impact on BMD of treating vitamin D deficiency (and osteomalacia) is also rarely considered in such intervention studies. When considering osteoporosis, fracture risk is our main concern, but vitamin D therapy has no consistent fracture-prevention effect, except in studies where calcium is coprescribed (particularly in frail populations living in care homes). As a J-shaped effect on falls and fracture risk is becoming evident with vitamin D interventions, we should target those at greatest risk who may benefit from vitamin D supplementation to decrease falls and fractures, although the optimum dose is still unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.