Evidence map›Paper›PMID 28382037›Full record

ArticleFrontiers in immunology2017

Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors.

Behdad Zarnegar, Erika Mendez-Enriquez, Annika Westin, Cecilia Söderberg, Joakim S Dahlin, Kjell-Olov Grönvik, Jenny Hallgren

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Circulating mast cell progenitors correlate with reduced lung function in allergic asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Trial
  2. Validation of Lung [Molecular imaging and biology · 2025
    Article
  3. Article
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  6. Review
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  8. Elastase- and LPS-Exposed Cpa3Frontiers in immunology · 2022
    Article
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  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Mast Cell Responses to Viruses and Pathogen Products.International journal of molecular sciences · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Behdad ZarnegarDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University , Uppsala , Sweden.
Erika Mendez-EnriquezDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University , Uppsala , Sweden.
Annika WestinDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University , Uppsala , Sweden.
Cecilia SöderbergDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University , Uppsala , Sweden.
Joakim S DahlinDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University , Uppsala , Sweden.
Kjell-Olov GrönvikDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden; Uppsala Immunobiology Lab, National Veterinary Institute, Uppsala, Sweden.
Jenny HallgrenDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University , Uppsala , Sweden.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cells (MCs) are powerful immune cells that mature in the peripheral tissues from bone marrow (BM)-derived mast cell progenitors (MCp). Accumulation of MCs in lung compartments where they are normally absent is thought to enhance symptoms in asthma. The enrichment of lung MCs is also observed in mice subjected to models of allergic airway inflammation. However, whether other types of lung inflammation trigger increased number of MCp, which give rise to MCs, is unknown. Here, mouse-adapted H1N1 influenza A was used as a model of respiratory virus infection. Intranasal administration of the virus induced expression of VCAM-1 on the lung vascular endothelium and an extensive increase in integrin β7

Indexed as

influenzalungmast cell progenitorsmast cellsrecruitmentvirus

Identifiers

PMID28382037
PMCPMC5360735
OpenAlexW2598139181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.