Evidence map›Paper›PMID 28381580›Full record

ArticleJournal of virology2017

Development of an Alternative Modified Live Influenza B Virus Vaccine.

Jefferson J S Santos, Courtney Finch, Troy Sutton, Adebimpe Obadan, Isabel Aguirre, Zhimin Wan, Diego Lopez, Ginger Geiger, Ana Silvia Gonzalez-Reiche, Lucas Ferreri and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jefferson J S SantosDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA.ORCID http://orcid.org/0000-0001-5895-4163
Courtney FinchVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Troy SuttonVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Adebimpe ObadanDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA.
Isabel AguirreDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA.
Zhimin WanDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA.
Diego LopezVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Ginger GeigerDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA.
Ana Silvia Gonzalez-ReicheDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA.
Lucas FerreriDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA.
Daniel R PerezDepartment of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, Georgia, USA dperez1@uga.edu.ORCID http://orcid.org/0000-0002-6569-5689
University of Georgia · USVirginia–Maryland College of Veterinary Medicine · US

Funding

NIAID NIH HHS HHSN266200700010CNIAID NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV hemagglutinin (HA) lineages cocirculate worldwide with little cross-reactivity. Live attenuated influenza virus (LAIV) vaccines have been shown to provide better cross-protective immune responses than inactivated vaccines by eliciting local mucosal immunity and systemic B cell- and T cell-mediated memory responses. We have shown previously that incorporation of temperature-sensitive (

Indexed as

Amino AcidsAnimalsAntigenic VariationGenome, ViralHumansImmunity, HumoralInfluenza B virusInfluenza, HumanInfluenza VaccinesLungMiceMutationOrthomyxoviridae InfectionsT-LymphocytesVaccines, AttenuatedVaccines, InactivatedAmino AcidsInfluenza VaccinesVaccines, AttenuatedVaccines, Inactivatedantigenic variationhumoral immunityinfluenza Binfluenza vaccineslive vector vaccinesorthomyxovirusT cell immunityviral immunity

Identifiers

PMID28381580
PMCPMC5446642
OpenAlexW2605338772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.