ArticleScience translational medicine2017
Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models.
8 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 114 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer Patients Undergoing Radiation Therapy Prior to the Resection of Locally Advanced Tumors, and Idiopathic Pulmonary Fibrosis Patients
Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury
Collagen-targeted PET Imaging for Early Interstitial Lung Disease
NCT05619302 phase3active not recruitingnot on this mapstarted 2023, after this paper: background citation
Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis
Evaluation of PET/MR Enterography for Differentiation of Fibrotic and Inflammatory Strictures in Patients With Crohn's Disease Using a Collagen-binding Radiotracer.
NCT06377553 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation
PET/MRI Evaluation of Endometriosis Using Intercellular Matrix Radiopharmaceuticals
Advanced Imaging for Pulmonary Fibrosis
Advanced Imaging to Assess the Effect of Immunosuppression on Progressive Lung Fibrosis in Participants With Non-Idiopathic Pulmonary Fibrosis Interstitial Lung Disease
Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Effectiveness and mechanism of metformin in animal models of pulmonary fibrosis: A preclinical systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Dual αAmerican journal of respiratory and critical care medicine · 2025Trial
- Chemokine Receptor 2-targeted Molecular Imaging in Pulmonary Fibrosis. A Clinical Trial.American journal of respiratory and critical care medicine · 2021Trial
- PET Imaging in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- An inherent T cell-activating mRNA delivery carrier for in vivo CAR T generation.Nature materials · 2026Article
- Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026Review
- Collagen-binding ⁶⁸Ga-CBP8 PET/MR in Deep Pelvic Endometriosis: First-in-human Application.Molecular imaging and biology · 2026Article
- Novel biomarker of fibrosis in SSc-ILD.RMD open · 2026Article
- Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices.Bioactive materials · 2026Article
- Collagen hybridizing peptide imaging and delivery of therapeutic antibody in rheumatoid arthritis models.Nature communications · 2026Article
- Fibroblast activation protein inhibitor (FAPI) PET imaging in pulmonary fibrosis: pathophysiology, clinical utility, and emerging theranostic applications.Respiratory research · 2026Review
- Inhalation-Based Nanoparticle Drug Delivery Targeting the Diseased Lower Airways in Idiopathic Pulmonary Fibrosis.Pharmaceutics · 2026Review
- Influences of Ring Sizes and Chiral Substituents on Macrocyclic Chelators for ImprovingJACS Au · 2026Article
- Multidimensional lung imaging: integrated preclinical platforms enabling the identification of translational biomarkers for pulmonary research.Respiratory research · 2026Review
- Extracellular Matrix in Human Disease and Therapy: From Pathogenic Remodeling to Biomaterial Platforms and Precision Diagnostics.Biomedicines · 2026Review
- Collagen Imaging in Human Intracranial Aneurysms - a Translational Proof-of-Concept Study.Translational stroke research · 2026Article
- Affibody-based optical imaging probe for noninvasive detection of liver fibrosis.Theranostics · 2026Article
- Molecular MRI of Collagen Enables Evaluation of Fibrosis and Therapeutic Response in Venous Thrombosis.Circulation. Cardiovascular imaging · 2026Article
- Beyond perfusion: a review of peptide radiopharmaceuticals for cardiovascular imaging.Npj imaging · 2025Review
- Chest Imaging with a Collagen-Binding Probe-A Human Hydroxyproline Assay?American journal of respiratory and critical care medicine · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Pauline DésogèreAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0001-8620-4108
Luis F TapiasDivision of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-0064-460X
Lida P HaririDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Nicholas J RotileAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Tyson A RietzAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0003-4670-5279
Clemens K ProbstDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-5546-9143
Francesco BlasiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Helen DayAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Mari Mino-KenudsonDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-9092-2265
Paul WeinrebBiogen, Cambridge, MA 02142, USA.ORCID 0000-0002-0802-0052
Shelia M VioletteBiogen, Cambridge, MA 02142, USA.
Bryan C FuchsDivision of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Andrew M TagerDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-5826-918X
Michael LanutiDivision of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. caravan@nmr.mgh.harvard.edu mlanuti@mgh.harvard.edu.
Peter CaravanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. caravan@nmr.mgh.harvard.edu mlanuti@mgh.harvard.edu.ORCID 0000-0002-3179-6537
Harvard University · USBiogen (United States) · USMassachusetts General Hospital · US
Funding
Molecular Imaging of Liver FibrosisR01DK104956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TANABE, KENNETH K · 2015 to 2019
$2.7MPET Imaging of Pulmonary FibrosisR01HL131907 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, LANUTI, MICHAEL · 2016 to 2018
$2.3MInveon: A Triple Modality Biomedical Imaging SystemS10RR029495 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2010 to 2010
$1.3MPET Imaging of Pulmonary FibrosisR01HL116315 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2012 to 2014
$1.3MHPLC-ICP-MS SystemS10OD010650 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2013 to 2013
$371kIVIS Spectrum Imaging SystemS10RR025504 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI MOORE, ANNA · 2009 to 2009
$341kNCRR NIH HHS S10 RR029495NHLBI NIH HHS R01 HL116315NHLBI NIH HHS R01 HL131907NIDDK NIH HHS R01 DK104956NIH HHS S10 OD010650
Abstract
Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity, environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis (IPF)]. Overexpression of collagen is a hallmark of organ fibrosis. We describe a peptide-based positron emission tomography (PET) probe (
Indexed as
Positron-Emission TomographyAnimalsBleomycinCapillary PermeabilityCollagen Type IDisease Models, AnimalDisease ProgressionGallium RadioisotopesHumansIdiopathic Pulmonary FibrosisKidneyLungMaleMice, Inbred C57BLMolecular ProbesPulmonary FibrosisBleomycinCollagen Type IGallium RadioisotopesMolecular Probes
Identifiers
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Registered trials
NCT03535545ClinicalTrials.gov
NCT04485286ClinicalTrials.gov
NCT05417776ClinicalTrials.gov
NCT05619302ClinicalTrials.gov
NCT06252493ClinicalTrials.gov
NCT06377553ClinicalTrials.gov
and 2 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.