Evidence map›Paper›PMID 28381493›Full record

ArticleJournal of neurophysiology2017

Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms.

Ben D Richardson, David J Rossi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Behavioral decline in Shank3Molecular autism · 2024
    Article
  3. Behavioral regression in shank3Research square · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. The Cerebellar GABAHandbook of experimental pharmacology · 2018
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ben D RichardsonDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, Washington; and.
David J RossiDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, Washington; and rossid@vetmed.wsu.edu.
Washington State University · US

Funding

NEUROSTEROID MODULATION OF ETHANOL WITHDRAWAL SEVERITYR01AA012439 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI FINN, DEBORAH A., ROSSI, DAVID J · 2000 to 2017
$4.6M
NIAAA NIH HHS R01 AA012439
6 · The paper itself

Abstract

Variation in cerebellar sensitivity to alcohol/ethanol (EtOH) is a heritable trait associated with alcohol use disorder in humans and high EtOH consumption in rodents, but the underlying mechanisms are poorly understood. A recently identified cellular substrate of cerebellar sensitivity to EtOH, the GABAergic system of cerebellar granule cells (GCs), shows divergent responses to EtOH paralleling EtOH consumption and motor impairment phenotype. Although GCs are the dominant afferent integrator in the cerebellum, such integration is shared by unipolar brush cells (UBCs) in vestibulocerebellar lobes. UBCs receive both GABAergic and glycinergic inhibition, both of which may mediate diverse neurological effects of EtOH. Therefore, the impact of recreational concentrations of EtOH (~10-50 mM) on GABA

Indexed as

Inhibitory Postsynaptic PotentialsAlcohol DrinkingAnimalsCentral Nervous System DepressantsCerebellumDose-Response Relationship, DrugEthanolFemaleGABAergic Neuronsgamma-Aminobutyric AcidGlycineMaleMiceRatsRats, Sprague-DawleySynapsesCentral Nervous System DepressantsEthanolgamma-Aminobutyric AcidGlycinealcoholcerebellumunipolar brush cell

Identifiers

PMID28381493
PMCPMC5498730
OpenAlexW2605336164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.