Evidence map›Paper›PMID 28381481›Full record

ArticleEMBO reports2017

FKBP8 recruits LC3A to mediate Parkin-independent mitophagy.

Zambarlal Bhujabal, Åsa B Birgisdottir, Eva Sjøttem, Hanne B Brenne, Aud Øvervatn, Sabrina Habisov, Vladimir Kirkin, Trond Lamark, Terje Johansen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 267 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
267citing papers in PubMed, 1 pooled it
22.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

267 citing papers in PubMed, 1 synthesis or guideline pooled it, 404 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Regulation and roles of mammalian mitophagy.Nature reviews. Molecular cell biology · 2026
    Review
  4. Mitophagy coordinates organelle crosstalk in health and diseases.Signal transduction and targeted therapy · 2026
    Review
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207 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zambarlal BhujabalMolecular Cancer Research Group, Department of Medical Biology, University of Tromsø -The Arctic University of Norway, Tromsø, Norway.
Åsa B BirgisdottirMolecular Cancer Research Group, Department of Medical Biology, University of Tromsø -The Arctic University of Norway, Tromsø, Norway.
Eva SjøttemMolecular Cancer Research Group, Department of Medical Biology, University of Tromsø -The Arctic University of Norway, Tromsø, Norway.
Hanne B BrenneMolecular Cancer Research Group, Department of Medical Biology, University of Tromsø -The Arctic University of Norway, Tromsø, Norway.
Aud ØvervatnMolecular Cancer Research Group, Department of Medical Biology, University of Tromsø -The Arctic University of Norway, Tromsø, Norway.
Sabrina HabisovMerck KGaA, Darmstadt, Germany.
Vladimir KirkinMerck KGaA, Darmstadt, Germany.
Trond LamarkMolecular Cancer Research Group, Department of Medical Biology, University of Tromsø -The Arctic University of Norway, Tromsø, Norway.
Terje JohansenMolecular Cancer Research Group, Department of Medical Biology, University of Tromsø -The Arctic University of Norway, Tromsø, Norway terje.johansen@uit.no.ORCID 0000-0003-1451-9578
UiT The Arctic University of Norway · NOMerck (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitophagy, the selective removal of damaged or excess mitochondria by autophagy, is an important process in cellular homeostasis. The outer mitochondrial membrane (OMM) proteins NIX, BNIP3, FUNDC1, and Bcl2-L13 recruit ATG8 proteins (LC3/GABARAP) to mitochondria during mitophagy. FKBP8 (also known as FKBP38), a unique member of the FK506-binding protein (FKBP) family, is similarly anchored in the OMM and acts as a multifunctional adaptor with anti-apoptotic activity. In a yeast two-hybrid screen, we identified FKBP8 as an ATG8-interacting protein. Here, we map an N-terminal LC3-interacting region (LIR) motif in FKBP8 that binds strongly to LC3A both

Indexed as

MitophagyHeLa CellsHumansMembrane ProteinsMicrotubule-Associated ProteinsMitochondrial MembranesMitochondrial ProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Saccharomyces cerevisiaeTacrolimus Binding ProteinsTumor Suppressor ProteinsTwo-Hybrid System TechniquesUbiquitin-Protein LigasesBCL2 protein, humanBNIP3L protein, humanBNIP3 protein, humanFKBP8 protein, humanMAP1LC3A protein, humanMembrane ProteinsMicrotubule-Associated ProteinsMitochondrial Proteinsparkin proteinProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Tacrolimus Binding ProteinsTumor Suppressor ProteinsUbiquitin-Protein LigasesautophagyFKBP38FKBP8LC3Amitophagy

Identifiers

PMID28381481
PMCPMC5452039
OpenAlexW2604819250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.