ArticleComparative medicine2017
Effect of Isoflurane Anesthesia on Circadian Metabolism and Physiology in Rats.
Article in Comparative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation: a randomized controlled trial.BMC anesthesiology · 2024Trial
- CO and NPflugers Archiv : European journal of physiology · 2026Article
- A Single-Operator Jugular Vein Sampling Method for Repeated Blood Collection in Conscious Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Effects of remimazolam and propofol on sleep rhythm and delirium after spinal surgery in elderly patients.Perioperative medicine (London, England) · 2025Article
- Development and Validation of a 7-Day Postoperative Sleep Disturbance Predictive Nomogram in Non-Cardiovascular Surgical Patients: A Prospective Cohort Study of 3851 Adults.Nature and science of sleep · 2025Article
- Effects of Buprenorphine and Carprofen on Appetite in New Zealand White Rabbits (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease.Scientific reports · 2022Article
- Physiologic and Behavioral Effects in Mice Anesthetized with Isoflurane in a Red-tinted or a Traditional Translucent Chamber.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Age and sex influence the response in lipid metabolism of dehydrated Wistar rats.Scientific reports · 2022Article
- Acute Effects of Different Electroacupuncture Point Combinations to Modulate the Gut-Brain Axis in the Minipig Model.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context.Frontiers in physiology · 2022Review
- In Vivo Magnetic Resonance Spectroscopy of Hyperpolarized [1-Journal of magnetic resonance imaging : JMRI · 2021Article
- Longitudinal impact on rat cardiac tissue transcriptomic profiles due to acute intratracheal inhalation exposures to isoflurane.PloS one · 2021Article
- PER2 Regulates Reactive Oxygen Species Production in the Circadian Susceptibility to Ischemia/Reperfusion Injury in the Heart.Oxidative medicine and cellular longevity · 2021Article
- Sleep Disturbances After General Anesthesia: Current Perspectives.Frontiers in neurology · 2020Review
- Noninvasive evaluation of fat-carbohydrate metabolic switching in heart and contracting skeletal muscle.American journal of physiology. Endocrinology and metabolism · 2019Article
- Control of (pre)-analytical aspects in immunoassay measurements of metabolic hormones in rodents.Endocrine connections · 2018Review
- Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: a randomized controlled crossover trial.BMJ open diabetes research & care · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO2 anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO2 (70% CO2, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague-Dawley rats (Crl:SD; n = 6 per group) were maintained on a 12:12-h light:dark (300 lx; lights on, 0600) photoperiod. After 1 wk of acclimation, a series of 6 low-volume blood draws were collected by cardiocentesis under anesthesia using isoflurane (10 min or less) compared with CO2 (1 min or less) at a single circadian time point every 4 d (0400, 0800, 1200, 1600, 2000, or 2400) over 3 wk to assess arterial blood glucose, lactic acid, and potassium and plasma melatonin, leptin, insulin, total fatty acids, and corticosterone concentrations. Results revealed that plasma levels (mean ± SEM) of melatonin were low (11 ± 1 pg/mL) during the light phase in both groups but were significantly lower during the dark phase in the isoflurane group (48 ± 6 pg/mL) compared with the CO2 group (162 ± 18 pg/mL). In addition, prominent circadian rhythms of arterial plasma levels of corticosterone, glucose, total fatty acids, lactic acid, and potassium were altered in the isoflurane group compared with the CO2 group. These findings demonstrate that the normal circadian rhythms of endocrine physiology and metabolism observed during brief CO2 anesthesia in rats are markedly disrupted by isoflurane anesthesia.
Indexed as
Identifiers
28381314PMC5402733W2948707312What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.