ArticleBMC microbiology2017
Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers.
Article in BMC microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
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- The Acari Hypothesis, VII: accounting for the comorbidity of allergy with other contemporary medical conditions, especially metabolic syndrome.Frontiers in allergy · 2025Article
- Comparison of the bacterial microbiome in the pharynx and nasal cavity of persistent, intermittent carriers and non-carriers ofJournal of medical microbiology · 2024Article
- The antivirulent Staphylococcal sRNA SprC regulates CzrB efflux pump to adapt its response to zinc toxicity.RNA (New York, N.Y.) · 2024Article
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- Co-culturing withFrontiers in cellular and infection microbiology · 2024Article
- Exploring differentially expressed genes of Staphylococcus aureus exposed to human tonsillar cells using RNA sequencing.BMC microbiology · 2023Article
- Quality improvement study on the effectiveness of intranasal povidone-iodine decolonization on surgery patients.Infection prevention in practice · 2023Article
- Laser nasal surgery (Review).Experimental and therapeutic medicine · 2023Review
- Interference and co-existence of staphylococci and Cutibacterium acnes within the healthy human skin microbiome.Communications biology · 2022Article
- Selection ofFrontiers in cellular and infection microbiology · 2022Article
- Inflammatory Response AgainstFrontiers in immunology · 2022Article
- Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells.PLoS pathogens · 2021Article
- Key Role of Staphylococcal Fibronectin-Binding Proteins During the Initial Stage ofFrontiers in cellular and infection microbiology · 2021Article
- Article
- An outbreak of cutaneous abscesses caused by Panton-Valentine leukocidin-producing methicillin-susceptible Staphylococcus aureus among gold mine workers, South Africa, November 2017 to March 2018.BMC infectious diseases · 2020Article
- Bacterial Colonization of the Hospitalized Newborn: Competition Between Staphylococcus aureus and Staphylococcus epidermidis.The Pediatric infectious disease journal · 2019Article
- Review
- Evaluation of the Pig-Tailed Macaque (Macaca nemestrina) as a Model of Human Staphylococcus aureus Nasal Carriage.Infection and immunity · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers.
methodsPunch skin biopsies were taken from vestibulum nasi from healthy volunteers (S. aureus carriers and non-/intermittent carriers, n = 39) attending the population-based Tromsø 6 study. The tissue samples were processed as frozen sections before immunostaining with a specific S. aureus antibody, and finally evaluated by a confocal laser-scanning microscope.
resultsOur results suggest that S. aureus colonize both the upper and lower layers of the epidermis within the nasal epithelium of healthy individuals. The number of S. aureus in epidermis was surprisingly low. Intracellular localization of S. aureus in nasal tissue from healthy individuals was also detected.
conclusionsKnowledge of the exact localization of S. aureus in nasal tissue is important for the understanding of the host responses against S. aureus. Our results may have consequences for the eradication strategy of S. aureus in carriers, and further work can provide us with tools for targeted prevention of S. aureus colonisation and infection.
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