Evidence map›Paper›PMID 28380379›Full record

ArticleCell metabolism2017

β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.

Cristina Aguayo-Mazzucato, Mark van Haaren, Magdalena Mruk, Terence B Lee, Caitlin Crawford, Jennifer Hollister-Lock, Brooke A Sullivan, James W Johnson, Aref Ebrahimi, Jonathan M Dreyfuss and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 199 citations in OpenAlex.

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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Cristina Aguayo-MazzucatoJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Mark van HaarenJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Magdalena MrukJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Terence B LeeJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Caitlin CrawfordJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Jennifer Hollister-LockJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Brooke A SullivanJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
James W JohnsonJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Aref EbrahimiJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Jonathan M DreyfussJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02115, USA.
Jan Van DeursenDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Gordon C WeirJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
Susan Bonner-WeirJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA. Electronic address: susan.bonner-weir@joslin.harvard.edu.
Joslin Diabetes Center · USBoston University · USMayo Clinic · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
Physiological Factors Driving Maturation of Neonatal Beta CellsR01DK093909 · NIDDK · JOSLIN DIABETES CENTER · PI BONNER-WEIR, SUSAN · 2011 to 2015
$1.8M
Aging of the beta cell and type 2 diabetesR01DK110390 · NIDDK · JOSLIN DIABETES CENTER · PI BONNER-WEIR, SUSAN · 2017 to 2020
$1.7M
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK093909NIDDK NIH HHS R01 DK110390
6 · The paper itself

Abstract

We hypothesized that the known heterogeneity of pancreatic β cells was due to subpopulations of β cells at different stages of their life cycle with different functional capacities and that further changes occur with metabolic stress and aging. We identified new markers of aging in β cells, including IGF1R. In β cells IGF1R expression correlated with age, dysfunction, and expression of known age markers p16

Indexed as

Cellular SenescenceInsulin ResistanceAdolescentAdultAgedAgingAnimalsBiomarkersDiabetes Mellitus, Type 2FemaleFlow CytometryGene Expression Regulation, DevelopmentalGlucoseGreen Fluorescent ProteinsHemolytic Plaque TechniqueHumansBiomarkersGlucoseGreen Fluorescent ProteinsInsulinReceptor, IGF Type 1RNA, MessengerTP53BP1 protein, humanTumor Suppressor p53-Binding Protein 1aging markersbeta-cell heterogeneityislets

Identifiers

PMID28380379
PMCPMC5471618
OpenAlexW2604579271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.