ArticleCell metabolism2017
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
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Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers.
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195citing papers in PubMed
19.5field-weighted citation impact, top 1% of its field
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Who cites it
195 citing papers in PubMed, 319 citations in OpenAlex.
- Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.Gut microbes · 2026Review
- Sirtuins as Molecular Mediators of Caloric Restriction in the Pancreas: Implications for β-Cell Function, Metabolism, and Longevity.International journal of molecular sciences · 2026Review
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- Mechanistic and functional integration of sirtuin deacylases: from substrate specificity to biological outcomes.Glycoconjugate journal · 2026Review
- Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases.Biomolecules · 2026Review
- Beyond deacetylation: crosstalk mechanisms and context-dependent regulation of sirtuin non-classical enzymatic functions in disease.Molecular medicine (Cambridge, Mass.) · 2026Review
- Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice.Nature communications · 2026Article
- The role of SIRT4 in obesity: from molecular mechanisms to clinical implications.International journal of obesity (2005) · 2026Review
- Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism.Nature chemical biology · 2025Article
- Transcription factor CEBPA suppresses sepsis induced lung injury by activating SIRT4 transcription.Scientific reports · 2025Article
- Article
- Structural basis of SIRT2 pre-catalysis NADRSC chemical biology · 2025Article
- SIRT7 regulates T-cell antitumor immunity through modulation BCAA and fatty acid metabolism.Cell death and differentiation · 2025Article
- Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential.Cell death discovery · 2025Review
- Histone deacetylase 9 modulates the acetylation dynamics of phototropin 1 to fine-tune phototropic responses in plants.Plant communications · 2025Article
- Mitochondrial sirtuins, key regulators of aging.Life medicine · 2025Review
- Association between mitochondrial SIRTs (SIRT3, SIRT4, and SIRT5) and PCOS.European journal of medical research · 2025Article
- Islet hormones at the intersection of glucose and amino acid metabolism.Nature reviews. Endocrinology · 2025Review
- Metabolic origin and significance of 3-methylglutaryl CoA.Clinica chimica acta; international journal of clinical chemistry · 2025Review
- SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice.bioRxiv : the preprint server for biology · 2025Article
135 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 2 countries.
Kristin A AndersonDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Frank K HuynhDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Kelsey Fisher-WellmanDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
J Darren StuartDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Brett S PetersonDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Jonathan D DourosDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Gregory R WagnerDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
J Will ThompsonDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Duke Proteomics and Metabolomics Shared Resource, Duke University Medical Center, Durham, NC 27710, USA.
Andreas S MadsenCenter for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Michelle F GreenDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
R Michael SivleyDepartment of Biological Sciences, Department of Biomedical Informatics, Vanderbilt Genetics Institute, Center for Structural Biology, Vanderbilt University, Nashville, TN 37235, USA.
Olga R IlkayevaDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Robert D StevensDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Donald S BackosComputational Chemistry and Biology Core Facility, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
John A CapraDepartment of Biological Sciences, Department of Biomedical Informatics, Vanderbilt Genetics Institute, Center for Structural Biology, Vanderbilt University, Nashville, TN 37235, USA.
Christian A OlsenCenter for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Jonathan E CampbellDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA.
Deborah M MuoioDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA.
Paul A GrimsrudDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Matthew D HirscheyDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: matthew.hirschey@duke.edu.
Duke University · USDuke Medical Center · USDuke University Hospital · USUniversity of Copenhagen · DKVanderbilt University · USUniversity of Montana · US
Funding
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MResource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6MREVERSIBLE MITOCHONDRIAL PROTEIN ACETYLATION AND METABOLIC REGULATIONR24DK085610 · NIDDK · J. DAVID GLADSTONE INSTITUTES · PI VERDIN, ERIC M. · 2010 to 2019
$16.0MPharmacological Sciences Training ProgramT32GM007105 · NIGMS · DUKE UNIVERSITY · PI KUHN, CYNTHIA M · 1985 to 2019
$9.0MRole of Carnitine Acetyltransferase in Mitochondrial and Metabolic FunctionR01DK089312 · NIDDK · DUKE UNIVERSITY · PI DEBORAH M MUOIO · 2010 to 2026
$7.8MEndocrinology and Metabolism Training ProgramT32DK007012 · NIDDK · DUKE UNIVERSITY · PI DAVID A. D'ALESSIO · 1986 to 2026
$6.8MStudies on the Mechanisms by which SIRT5 Regulates Aging and DiseaseR01AG045351 · NIA · DUKE UNIVERSITY · PI HIRSCHEY, MATTHEW D · 2014 to 2023
$4.4MCANCER BIOLOGY TRAINING GRANTT32CA059365 · NCI · DUKE UNIVERSITY · PI WANG, XIAO-FAN · 1993 to 2014
$4.4MTraining Program in Quantitative Ocular GenomicsT32EY021453 · NEI · VANDERBILT UNIVERSITY · PI BRANTLEY, MILAM A, COX, NANCY J · 2011 to 2020
$1.4MNovel SIRT4 Enzymatic Activity Influence Cellular Mechanisms of AgingR56AG052568 · NIA · DUKE UNIVERSITY · PI HIRSCHEY, MATTHEW D · 2016 to 2016
$398kRole of Protein Malonylation in Regulating Mitochondrial FunctionF32DK105665 · NIDDK · DUKE UNIVERSITY · PI FISHER-WELLMAN, KELSEY · 2015 to 2017
$130kNCATS NIH HHS UL1 TR001082NCI NIH HHS T32 CA059365NEI NIH HHS T32 EY021453NIA NIH HHS P30 AG028716NIA NIH HHS R01 AG045351NIA NIH HHS R56 AG052568NIDDK NIH HHS F32 DK105665NIDDK NIH HHS R01 DK089312NIDDK NIH HHS R24 DK085610NIDDK NIH HHS T32 DK007012NIGMS NIH HHS T32 GM007105
Abstract
Sirtuins are NAD
Indexed as
AmidohydrolasesAmino Acid SequenceAnimalsCarbon-Carbon LigasesGlucoseHEK293 CellsHomeostasisHumansInsulinInsulin ResistanceInsulin SecretionLeucineLysineMetabolic Flux AnalysisMice, Inbred C57BLMice, KnockoutAmidohydrolasesCarbon-Carbon LigasesGlucoseInsulinLeucineLysinemethylcrotonoyl-CoA carboxylaseMitochondrial ProteinsSIRT4 protein, mouseSirtuinsbranched-chain amino acidsdeacylaseinsulin secretionleucinemitochondriasirtuin 4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.