ArticleDrug and alcohol dependence2017
Preliminary test of cigarette nicotine discrimination threshold in non-dependent versus dependent smokers.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regulatory Approaches and Implementation of Minimally Addictive Combusted Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Pooled it
- Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans.Psychopharmacology · 2024Article
- Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration.Experimental and clinical psychopharmacology · 2023Article
- Acute nicotine reinforcement requires ability to discriminate the stimulus effects of nicotine.Experimental and clinical psychopharmacology · 2022Review
- A review of the evidence on cigarettes with reduced addictiveness potential.The International journal on drug policy · 2022Review
- Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers.Psychopharmacology · 2021Article
- Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers.Psychopharmacology · 2021Article
- A Forced-Choice Procedure to Assess the Acute Relative Reinforcing Effects of Nicotine Dose per se in Humans.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Using Product Standards to Render the Most Harmful Tobacco Products Minimally Addictive: Maximum Nicotine Level, Non-Nicotine Constituents, and Scope.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Research on Behavioral Discrimination of Nicotine May Inform FDA Policy on Setting a Maximum Nicotine Content in Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Sweet flowers are slow, and weeds make haste: leveraging methodology from research on tobacco, alcohol, and opioid analgesics to make rapid and policy-relevant advances in cannabis science.International review of psychiatry (Abingdon, England) · 2018Review
- Threshold dose for behavioral discrimination of cigarette nicotine content in menthol vs. non-menthol smokers.Psychopharmacology · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundDespite its potential for understanding tobacco dependence, behavioral discrimination of nicotine via smoking has not been formally examined as a function of nicotine dependence level.
methodsSpectrum research cigarettes were used to compare non-dependent with dependent smokers on the lowest content of nicotine they could discriminate (i.e., "threshold"). Dependent (n=21; 16M, 5F) or non-dependent (n=7; 4M, 3F) smokers were tested on ability to discriminate between cigarettes with nicotine contents of 17, 11, 5, 2, and 1mg/g, one per session, from an "ultra-low" cigarette with 0.4mg/g (all had 9-10mg "tar"). All abstained from smoking overnight prior to sessions, and number of sessions was determined by the lowest nicotine content they could reliably discriminate from the ultra-low on >80% of trials (i.e., ≥5 of 6). Subjective perceptions and cigarette choice behavior were also assessed and related to discrimination behavior.
resultsDiscrimination thresholds (and most perceptions) did not differ between dependent and non-dependent smokers, with median thresholds of 11mg/g for both subgroups. Yet, "liking" and puff choice for threshold cigarettes were greater in dependent but not non-dependent smokers, while cigarettes with nicotine contents below threshold did not support "liking" or choice in both groups.
conclusionsIn sum, this preliminary study suggests threshold for discriminating nicotine via smoking may not vary by dependence level, and further study is needed to confirm that cigarettes unable to be discriminated are also not reinforcing.
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