ArticlePloS one2017
Carbapenemase-producing enterobacteriaceae recovered from a Spanish river ecosystem.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Carbapenem-resistant Enterobacteriaceae in the livestock, humans and environmental samples around the globe: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Clinically Significant Carbapenemases in Gram-Negative Pathogens: Molecular Diversity and Advances in β-Lactamase Inhibitor Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Virulence arsenal of Acinetobacter baumannii: mechanisms driving persistence and resistance.Archives of microbiology · 2026Review
- Environmental Dispersion of MultiresistantAntibiotics (Basel, Switzerland) · 2025Article
- Two virulent bacteriophages targeting carbapenem-resistantFrontiers in microbiology · 2025Article
- Comparison of the Antibiotic Resistance ofPathogens (Basel, Switzerland) · 2024Article
- Emergence of NDM-1-producingVeterinary world · 2023Article
- Phenotypic and Molecular Characterization of an Enterobacter ludwigii Clinical Isolate Carrying a Plasmid-MediatedMicrobiology spectrum · 2023Article
- Mobile resistome of microbial communities and antimicrobial residues from drinking water supply systems in Rio de Janeiro, Brazil.Scientific reports · 2022Article
- Antibiotic Resistance in the Finfish Aquaculture Industry: A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Clonal Complexes 23, 10, 131 and 38 as Genetic Markers of the Environmental Spread of Extended-Spectrum β-Lactamase (ESBL)-ProducingAntibiotics (Basel, Switzerland) · 2022Article
- KPC-3-, GES-5-, and VIM-1-ProducingInternational journal of environmental research and public health · 2022Article
- Dissemination of a single ST11 clone of OXA-48-producingMicrobial genomics · 2022Article
- Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence.Clinical microbiology reviews · 2022Article
- Detection of an IMI-2 carbapenemase-producingFrontiers in microbiology · 2022Article
- Association of Carbapenemase-ProducingFrontiers in microbiology · 2022Article
- Multidrug-resistant Raoultella ornithinolytica misidentified as Klebsiella oxytoca carrying blaOXA β-lactamases: antimicrobial profile and genomic characterization.Archives of microbiology · 2021Article
- Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment.Environmental geochemistry and health · 2021Review
- Epidemic HI2 Plasmids Mobilising the Carbapenemase GeneMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing resistance to carbapenems is an alarming threat in the fight against multiresistant bacteria. The dissemination properties of antimicrobial resistance genes are supported by their detection in a diverse population of bacteria, including strains isolated from the environment. The objective of this study was to investigate the presence of carbapenemase-producing Enterobacteriaceae (CPE) collected from a river ecosystem in the Barcelona metropolitan area (Spain). Identification of β-lactamases and other resistance determinants was determined as was the antimicrobial susceptibility profile. Moreover, screening of virulence factors, plasmid addiction systems, plasmid partition systems and replicon typing was performed. The results identified 8 isolates belonging to different species (Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, Raoultella ornithinolytica). The most prevalent enzyme was KPC-2 (n = 6), followed by VIM-1 (n = 2) and IMI-2 (n = 1), whereas no OXA-48-type was detected. In addition, one strain was positive for both KPC-2 and VIM-1 enzymes. All the carbapenemase-encoding plasmids carried at least one plasmid addiction or partition system, being vagCD and parAB the most frequently detected, respectively. E. coli and K. pneumoniae isolates carried a low number of virulence-associated factors and none of the detected clones has previously been identified in the clinical setting. These findings support the high dissemination potential of the carbapanemase-encoding genes and reinforce the idea that the environment is another reservoir that may play an important role in the capture, selection and dissemination of carbapenem resistance genes.
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