ArticlePLoS genetics2017
TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The regenerative period of somatosensory nerves is closed by a DCC signaling axis.PLoS genetics · 2026Article
- Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous irg1/acod1 tracking.Nature communications · 2026Article
- Aging-related NADPH diaphorase positive neurodegenerations in the sacral spinal cord of aged non-human primates.Scientific reports · 2024Article
- Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia.PLoS biology · 2024Article
- Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia.bioRxiv : the preprint server for biology · 2024Article
- Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage.Frontiers in cellular neuroscience · 2024Review
- A Subset of Oligodendrocyte Lineage Cells Interact With the Developing Dorsal Root Entry Zone During Its Genesis.Frontiers in cellular neuroscience · 2022Article
- Pioneer Axons Utilize aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Transparent Touch: Insights From Model Systems on Epidermal Control of Somatosensory Innervation.Frontiers in cellular neuroscience · 2021Review
- Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1.Frontiers in immunology · 2020Article
- Article
- Generating intravital super-resolution movies with conventional microscopy reveals actin dynamics that construct pioneer axons.Development (Cambridge, England) · 2019Article
- Pioneer axons employ Cajal's battering ram to enter the spinal cord.Nature communications · 2019Article
- Microglia exit the CNS in spinal root avulsion.PLoS biology · 2019Article
- Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.Neural development · 2018Article
- Reconstruction of the Damaged Dorsal Root Entry Zone by Transplantation of Olfactory Ensheathing Cells.Cell transplantationArticle
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Somatosensory information from the periphery is routed to the spinal cord through centrally-projecting sensory axons that cross into the central nervous system (CNS) via the dorsal root entry zone (DREZ). The glial cells that ensheath these axons ensure rapid propagation of this information. Despite the importance of this glial-axon arrangement, how this afferent nerve is assembled during development is unknown. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2)-mediated process. This work identifies a signaling cascade that mediates peripheral glial-axon interactions and it functions to ensure that DRG afferent projections are ensheathed after pioneer axons complete their navigation, which promotes efficient somatosensory neural function.
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Registered trials
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