ArticlePloS one2017
The origin and evolution of fibromelanosis in domesticated chickens: Genomic comparison of Indonesian Cemani and Chinese Silkie breeds.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Visceral Peritoneum Hyperpigmentation in Chickens Is Associated withAnimals : an open access journal from MDPI · 2025Article
- The genomic structure of complex chromosomal rearrangement at the Fm locus in black-bone Silkie chicken.Communications biology · 2025Article
- Population genomic analysis identifies the complex structural variation at the fibromelanosis (FM) locus in chicken.Scientific reports · 2025Article
- Common Ancestry of the Id Locus: Chromosomal Rearrangement and Polygenic Possibilities.Journal of molecular evolution · 2025Article
- Revealing the complete mtDNA genome sequence of Cemani chicken (Gallus gallus) by using Nanopore sequencing analysis.Animal bioscience · 2024Article
- Genomic and transcriptomic landscape to decipher the genetic basis of hyperpigmentation in Lanping black-boned sheep (Ovis aries).BMC genomics · 2024Article
- Characterization of the Coding Sequence of theAnimals : an open access journal from MDPI · 2024Article
- A comparative review on Ayam Cemani chicken - A comparison with the most common chicken species in terms of nutritional values, LCA, price and consumer acceptance.Tropical animal health and production · 2024Review
- Calling Structural Variants with Confidence from Short-Read Data in Wild Bird Populations.Genome biology and evolution · 2024Article
- A chromosome-level genome assembly for the Silkie chicken resolves complete sequences for key chicken metabolic, reproductive, and immunity genes.Communications biology · 2023Article
- Chloroplast genome sequence of triploid Toxicodendron vernicifluum and comparative analyses with other lacquer chloroplast genomes.BMC genomics · 2023Article
- Decoding the fibromelanosis locus complex chromosomal rearrangement of black-bone chicken: genetic differentiation, selective sweeps and protein-coding changes in Kadaknath chicken.Frontiers in genetics · 2023Article
- Carcass Characteristics, Meat Quality and Nutritional Composition of Kadaknath, a Native Chicken Breed of India.Foods (Basel, Switzerland) · 2022Article
- Single nucleotide polymorphism marker combinations for classifying Yeonsan Ogye chicken using a machine learning approach.Journal of animal science and technology · 2022Article
- Genome Structural Variation Landscape and Its Selection Signatures in the Fast-growing Strains of the Pacific Oyster, Crassostrea gigas.Marine biotechnology (New York, N.Y.) · 2021Article
- A retroviral insertion in the tyrosinase (Journal of animal science and technology · 2021Article
- Shifts in growth, but not differentiation, foreshadow the formation of exaggerated forms under chicken domestication.Proceedings. Biological sciences · 2021Article
- Mitochondrial DNA diversity and demographic history of Black-boned chickens in China.Mitochondrial DNA. Part B, Resources · 2021Article
- Chloroplast genome sequence of Chongming lima bean (Phaseolus lunatus L.) and comparative analyses with other legume chloroplast genomes.BMC genomics · 2021Article
- Breeding history and candidate genes responsible for black skin of Xichuan black-bone chicken.BMC genomics · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like Chinese Silkie, Indonesian Ayam Cemani exhibits fibromelanosis or dermal hyperpigmentation and possesses complex segmental duplications on chromosome 20 that involve the endothelin 3 gene, EDN3. A genomic region, DR1 of 127 kb, together with another region, DR2 of 171 kb, was duplicated by unequal crossing over, accompanied by inversion of one DR2. Quantitative PCR and copy number variation analyses on the Cemani genome sequence confirmed the duplication of EDN3. These genetic arrangements are identical in Cemani and Silkie, indicating a single origin of the genetic cause of Fm. The two DR1s harbor two distinct EDN3 haplotypes in a form of permanent heterozygosity, although they remain allelic in the ancestral Red Jungle Fowl population and some domesticated chicken breeds, with their allelic divergence time being as recent as 0.3 million years ago. In Cemani and Silkie breeds, artificial selection favoring the Fm phenotype has left an unambiguous record for selective sweep that extends in both directions from tandemly duplicated EDN3 loci. This highly homozygous tract is different in length between Cemani and Silkie, reflecting their distinct breeding histories. It is estimated that the Fm phenotype came into existence at least 6600-9100 years ago, prior to domestication of Cemani and Silkie, and that throughout domestication there has been intense artificial selection with strength s > 50% in each breed.
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