ArticleInvestigative radiology2017
Improved Magnetic Resonance Imaging-Pathology Correlation With Imaging-Derived, 3D-Printed, Patient-Specific Whole-Mount Molds of the Prostate.
Article in Investigative radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- The Use of Additive Manufacturing Techniques in the Development of Polymeric Molds: A Review.Polymers · 2024Review
- Lesion-specific 3D-printed moulds for image-guided tissue multi-sampling of ovarian tumours: A prospective pilot study.Frontiers in oncology · 2023Article
- Using IVIM Parameters to Differentiate Prostate Cancer and Contralateral Normal Tissue through Fusion of MRI Images with Whole-Mount Pathology Specimen Images by Control Point Registration Method.Diagnostics (Basel, Switzerland) · 2021Article
- Automated detection of aggressive and indolent prostate cancer on magnetic resonance imaging.Medical physics · 2021Article
- Additive Manufacturing of Resected Oral and Oropharyngeal Tissue: A Pilot Study.International journal of environmental research and public health · 2021Article
- Pathological validation and prognostic potential of quantitative MRI in the characterization of pancreas cancer: preliminary experience.Molecular oncology · 2020Article
- Three-Dimensional Printed Molds for Image-Guided Surgical Biopsies: An Open Source Computational Platform.JCO clinical cancer informatics · 2020Article
- Liver-specific 3D sectioning molds for correlating in vivo CT and MRI with tumor histopathology in woodchucks (Marmota monax).PloS one · 2020Article
- Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI.PloS one · 2020Article
- Improved co-registration of ex-vivo and in-vivo cardiovascular magnetic resonance images using heart-specific flexible 3D printed acrylic scaffold combined with non-rigid registration.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- Genomic Evaluation of Multiparametric Magnetic Resonance Imaging-visible and -nonvisible Lesions in Clinically Localised Prostate Cancer.European urology oncology · 2019Article
- MR Imaging-Histology Correlation by Tailored 3D-Printed Slicer in Oncological Assessment.Contrast media & molecular imaging · 2019Review
- Article
- Targeting phenotypic heterogeneity in benign prostatic hyperplasia.Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe aim of this study was to compare the anatomical registration of preoperative magnetic resonance imaging (MRI) and prostate whole-mount obtained with 3D-printed, patient-specific, MRI-derived molds (PSM) versus conventional whole-mount sectioning (WMS). MATERIALS AND
methodsBased on an a priori power analysis, this institutional review board-approved study prospectively included 50 consecutive men who underwent 3 T multiparametric prostate MRI followed by radical prostatectomy. Two blinded and independent readers (R1 and R2) outlined the contours of the prostate, tumor, peripheral, and transition zones in the MRI scans using regions of interest. These were compared with the corresponding regions of interest from the whole-mounted histopathology, the reference standard, using PSM whole-mount results obtained in the study group (n = 25) or conventional WMS in the control group (n = 25). The spatial overlap across the MRI and histology data sets was calculated using the Dice similarity coefficient (DSC) for the prostate overall (DSCprostate), tumor (DSCtumor), peripheral (DSCPZ), and transition (DSCTZ) zone. Results in the study and control groups were compared using Wilcoxon rank sum test.
resultsThe MRI histopathology anatomical registration for the prostate gland overall, tumor, peripheral, and transition zones were significantly superior with the use of PSMs (DSCs for R1: 0.95, 0.86, 0.84, and 0.89; for R2: 0.93, 0.75, 0.78, and 0.85, respectively) than with the use of standard WMS (R1: 0.85, 0.46, 0.66, and 0.69; R2: 0.85, 0.46, 0.66, and 0.69) (P < 0.0001).
conclusionsThe use of PSMs for prostate specimen whole-mount sectioning provides significantly superior anatomical registration of in vivo multiparametric MRI and ex vivo prostate whole-mounts than conventional WMS.
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Registered trials
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