ArticlePhysics in medicine and biology2017
Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies.
Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction.IEEE transactions on bio-medical engineering · 2025Article
- Stress CMR in Known or Suspected CAD: Diagnostic and Prognostic Role.BioMed research international · 2021Review
- Selection of PET Camera and Implications on the Reliability and Accuracy of Absolute Myocardial Blood Flow Quantification.Current cardiology reports · 2020Review
- Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia.Nature reviews. Cardiology · 2020Article
- Recent methodology advances in fluorescence molecular tomography.Visual computing for industry, biomedicine, and art · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Dynamic PET myocardial perfusion imaging (MPI) used in conjunction with tracer kinetic modeling enables the quantification of absolute myocardial blood flow (MBF). However, MBF maps computed using the traditional indirect method (i.e. post-reconstruction voxel-wise fitting of kinetic model to PET time-activity-curves-TACs) suffer from poor signal-to-noise ratio (SNR). Direct reconstruction of kinetic parameters from raw PET projection data has been shown to offer parametric images with higher SNR compared to the indirect method. The aim of this study was to extend and evaluate the performance of a direct parametric reconstruction method using in vivo dynamic PET MPI data for the purpose of quantifying MBF. Dynamic PET MPI studies were performed on two healthy pigs using a Siemens Biograph mMR scanner. List-mode PET data for each animal were acquired following a bolus injection of ~7-8 mCi of
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