ArticleACS chemical biology2017
The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock.
Article in ACS chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Three diketomorpholines from a Penicillium sp. (strain G1071).Phytochemistry · 2021Article
- Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules.
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Registered trials
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